Phenotypes associated with this allele

• Allele Symbol: Dnah11^tm1Ssp
• Allele Name: targeted mutation 1, S Steven Potter
• Allele ID: MGI:2152963
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnah11^tm1Ssp/Dnah11^tm1Ssp	Not Specified	MGI:3622123

Genotype
MGI:3622123

hm1

• Allelic Composition: Dnah11^tm1Ssp/Dnah11^tm1Ssp
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal motile primary cilium physiology ( J:44522 )

• monocilia in the nodes of E7.5 embryos are rigid and immotile

absent nodal flow ( J:44522 )

abnormal left-right axis patterning ( J:44522 )

• exhibit randomization of laterality

• 12 of 31 show complete reversal of positioning of the lungs, heart, stomach, liver, and spleen

• 2 homozygotes show heterotaxia, a discordant positioning of individual organs within the same animal, with the heart and liver normal, but the stomach and spleen reversed

abnormal primitive node morphology ( J:44522 )

growth/size/body

right-sided stomach ( J:44522 )

• about 50% of neonates have inverted right-sided stomachs

left pulmonary isomerism ( J:44522 )

• 2 homozygotes have left lung isomerism, with one having a normal situs and the other a reversed situs

situs inversus ( J:44522 )

• 2 of 31 show complete reversal of positioning of the lungs, heart, stomach, liver, and spleen

digestive/alimentary system

right-sided stomach ( J:44522 )

• about 50% of neonates have inverted right-sided stomachs

respiratory system

left pulmonary isomerism ( J:44522 )

• 2 homozygotes have left lung isomerism, with one having a normal situs and the other a reversed situs

cellular

abnormal motile primary cilium physiology ( J:44522 )

• monocilia in the nodes of E7.5 embryos are rigid and immotile

absent nodal flow ( J:44522 )