Analysis Tools
mortality/aging
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• 2% of mice die within 2 to 4 months
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• 11% of mice die three weeks after birth
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hematopoietic system
small thymus
(
J:62230
)
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• in affected mice
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• the thymus weight to kidney weight or body weight in affected mice is decreased 0.21% to 0.32% of wild-type
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• affected mice exhibit a 3.5-fold decrease in thymus cellularity due to a lack of lymphocytes emigrating from the marrow
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• affected mice exhibit a depletion of immature cortical thymocytes (CD4+CD8+ double positive cells) compared to in wild-type mice
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• in affected mice
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• affected mice exhibit a depletion of immature cortical thymocytes (CD4+CD8+ double positive cells) compared to in wild-type mice
• however, the number of CD4 and CD8 single positive cells is normal
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• in affected mice erythroblasts are decreased to 50% of wild-type mice
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• decreased by 45% in affected mice
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• in the spleen of affected mice
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• in affected mice
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• the spleen is discolored in affected mice
• affected mice exhibit poorly defined lymphatic nodules and severely decreased red pulp compared with wild-type mice
• lymphatic nodules of affected mice are smaller and less-organized with decreased internodular space compared to in wild-type mice
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small spleen
(
J:62230
)
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• in affected mice
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• the spleen weight to kidney weight or body weight is decreased 0.12% to 0.16% of wild-type in affected mice
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• 7.7-fold in affected mice
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skeleton
| N |
• mice exhibit normal long bone growth and development
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• 1% to 2% of mice exhibit tooth overgrowth
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• affected mice exhibit a 14% decrease in the tibia growth plate width compared with wild-type mice
• affected mice exhibit an increase in waviness of the tibia growth plate unlike in wild-type mice
• affected mice exhibit more pronounced and somewhat variable tibia growth plate compared with wild-type mice
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• more compressed than the hypertrophic zone in affected mice
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• 2 of 30 mice exhibit abnormal ossification of the second cervical vertebra characterized by malformed cartilage and an extra piece of bone in the neural arch region
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• the marrow of affected mice is bright red and erythrocyte-filled unlike in wild-type mice
• the bone marrow of affected mice is depleted of leukocytes
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• trabecular bony spicules of affected mice are slightly reduced in size and number compared to in wild-type mice
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growth/size/body
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• 1% to 2% of mice exhibit tooth overgrowth
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• affected mice exhibit dwarfism and weight one third as much as wild-type mice
• however, mice that survive beyond weaning recover
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behavior/neurological
craniofacial
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• 1% to 2% of mice exhibit tooth overgrowth
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nervous system
hydrocephaly
(
J:62230
)
|
• in 1% to 2% of mice
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immune system
small thymus
(
J:62230
)
|
• in affected mice
|
|
• the thymus weight to kidney weight or body weight in affected mice is decreased 0.21% to 0.32% of wild-type
|
|
• affected mice exhibit a 3.5-fold decrease in thymus cellularity due to a lack of lymphocytes emigrating from the marrow
|
|
• affected mice exhibit a depletion of immature cortical thymocytes (CD4+CD8+ double positive cells) compared to in wild-type mice
|
|
• in affected mice
|
|
• affected mice exhibit a depletion of immature cortical thymocytes (CD4+CD8+ double positive cells) compared to in wild-type mice
• however, the number of CD4 and CD8 single positive cells is normal
|
|
• decreased by 45% in affected mice
|
|
• in the spleen of affected mice
|
|
• in affected mice
|
|
• the spleen is discolored in affected mice
• affected mice exhibit poorly defined lymphatic nodules and severely decreased red pulp compared with wild-type mice
• lymphatic nodules of affected mice are smaller and less-organized with decreased internodular space compared to in wild-type mice
|
small spleen
(
J:62230
)
|
• in affected mice
|
|
• the spleen weight to kidney weight or body weight is decreased 0.12% to 0.16% of wild-type in affected mice
|
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• 7.7-fold in affected mice
|
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• in affected mice
|
endocrine/exocrine glands
small thymus
(
J:62230
)
|
• in affected mice
|
|
• the thymus weight to kidney weight or body weight in affected mice is decreased 0.21% to 0.32% of wild-type
|
|
• affected mice exhibit a 3.5-fold decrease in thymus cellularity due to a lack of lymphocytes emigrating from the marrow
|
|
• affected mice exhibit a depletion of immature cortical thymocytes (CD4+CD8+ double positive cells) compared to in wild-type mice
|
