All Phenotypes Fga<tm1Jld> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fga^tm1Jld/Fga^tm1Jld	B6.129P2-Fga^tm1Jld	MGI:3663779
hm2	Fga^tm1Jld/Fga^tm1Jld	involves: 129P2/OlaHsd * C57BL/6J	MGI:4834590
hm3	Fga^tm1Jld/Fga^tm1Jld	involves: 129P2/OlaHsd * CF-1	MGI:3663778
cx4	Fga^tm1Jld/Fga^tm1Jld Plg^tm1Jld/Plg^tm1Jld	B6.129P2-Fga^tm1Jld Plg^tm1Jld	MGI:3690628
cx5	Fga^tm1Jld/Fga^tm1Jld Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd	MGI:3690459
cx6	Fga^tm1Jld/Fga^tm1Jld Thbd^tm2Rdr/Thbd^tm2Rdr	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:2653115
cx7	Fga^tm1Jld/Fga^tm1Jld Vwf^tm1Wgr/Vwf^tm1Wgr	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:4834591
cx8	Fga^tm1Jld/Fga^tm1Jld Plg^tm1Jld/Plg^tm1Jld	involves: 129P2/OlaHsd * Black Swiss * CF-1	MGI:3690622

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld
Genetic Background	B6.129P2-Fga^tm1Jld

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fga^tm1Jld mutation (0 available); any Fga mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:28436 )

N	• Background Sensitivity: survival characteristics essentially normal although blood clotting defect remains

homeostasis/metabolism

decreased platelet aggregation ( J:28436 )

• platelet aggregation fails

decreased circulating fibrinogen level ( J:28436 )

• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver

• no other abnormal blood parameters

impaired blood coagulation ( J:28436 )

• blood unable to clot

cardiovascular system

uterine hemorrhage ( J:28436 )

• bleeding into uterine cavity

vaginal hemorrhage ( J:28436 )

• overt vaginal bleeding beginning about ten days into pregnancy

hemarthrosis ( J:28436 )

• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal

hemoperitoneum ( J:28436 )

• overt intra-abdominal and periumbilical bleeding develops within 2 days of birth in many mice

• Background Sensitivity: does not particularly affect survival

liver hemorrhage ( J:28436 )

• hepatic subcapsular hematomas developing into fibrotic scars

skin hemorrhage ( J:28436 )

• normal at birth

• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal

reproductive system

uterine hemorrhage ( J:28436 )

• bleeding into uterine cavity

vaginal hemorrhage ( J:28436 )

• overt vaginal bleeding beginning about ten days into pregnancy

abnormal uterine environment ( J:28436 )

• overt vaginal bleeding beginning about ten days into pregnancy

• about 1/3 die by day 12 of pregnancy

• bleeding into uterine cavity occurs

• embryo development arrested around day 9 to 10 of pregnancy

• death of embryos around time when trophoblasts invade and disrupt maternal vasculature

female infertility ( J:28436 )

• homozygous females fail to give birth to live offspring

nervous system

abnormal myelination ( J:75437 )

• increased numbers of myelinating fibers after crush injury of the sciatic nerve and less proliferation of Schwann cells

• by 35 days after nerve injury, recovery is comparable to controls

hematopoietic system

decreased platelet aggregation ( J:28436 )

• platelet aggregation fails

skeleton

hemarthrosis ( J:28436 )

• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal

immune system

decreased circulating fibrinogen level ( J:28436 )

• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver

• no other abnormal blood parameters

integument

skin hemorrhage ( J:28436 )

• normal at birth

• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal

liver/biliary system

liver hemorrhage ( J:28436 )

• hepatic subcapsular hematomas developing into fibrotic scars

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fga^tm1Jld mutation (0 available); any Fga mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:63750 )

• thrombi that form in FeCl3-treated mice fail to resist sheer stress and eventually break off unlike in similarly treated wild-type mice

• FeCl3-induced thrombi occlude vessels away from the site of injury unlike in similarly treated wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:28436 )

• Background Sensitivity: 90% survive to weaning

• Background Sensitivity: only half survive beyond 70 days of age with deaths usually due to intra-abdominal bleeding

• Background Sensitivity: survival curves for females slightly better than for males

• Background Sensitivity: risk of fatal bleeding greatest between 30 and 60 days

• Background Sensitivity: mice surviving beyond 2 months continue to survive well

homeostasis/metabolism

decreased circulating fibrinogen level ( J:28436 )

• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver

• no other abnormal blood parameters

abnormal blood coagulation ( J:36591 )

• exhibit distinctly larger deposits of dried blood at wound margins and scabs of wounds appear initially less stable than in controls and resumed bleeding is occasionally apparent

decreased platelet aggregation ( J:28436 )

• platelet aggregation fails

impaired blood coagulation ( J:28436 )

• blood unable to clot

abnormal wound healing ( J:36591 )

• exhibit distinctly larger deposits of dried blood at wound margins

• scabs of wounds appear initially less stable than in controls and resumed bleeding is occasionally apparent

cardiovascular system

uterine hemorrhage ( J:28436 )

• bleeding into uterine cavity

vaginal hemorrhage ( J:28436 )

• overt vaginal bleeding beginning about ten days into pregnancy

stomach hemorrhage ( J:36591 )

• 11% (1 of 9) show squamous stomach hemorrhage

hemarthrosis ( J:28436 )

• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal

hemoperitoneum ( J:28436 )

• overt intra-abdominal and periumbilical bleeding develops within 2 days of birth in many mice

• Background Sensitivity: results in death of mice that die between weaning and 70 days of age

liver hemorrhage ( J:28436 )

• hepatic subcapsular hematomas developing into fibrotic scars

subcutaneous hemorrhage ( J:28436 )

• normal at birth

• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal

reproductive system

uterine hemorrhage ( J:28436 )

• bleeding into uterine cavity

vaginal hemorrhage ( J:28436 )

• overt vaginal bleeding beginning about ten days into pregnancy

abnormal uterine environment ( J:28436 )

• overt vaginal bleeding beginning about ten days into pregnancy

• about 1/3 die by day 12 of pregnancy

• bleeding into uterine cavity occurs

• embryo development arrested around day 9 to 10 of pregnancy

• death of embryos around time when trophoblasts invade and disrupt maternal vasculature

female infertility ( J:28436 )

• homozygous females fail to give birth to live offspring

nervous system

abnormal myelination ( J:75437 )

• increased numbers of myelinating fibers after crush injury of the sciatic nerve and less proliferation of Schwann cells

• by 35 days after nerve injury, recovery is comparable to controls

hematopoietic system

decreased platelet aggregation ( J:28436 )

• platelet aggregation fails

skeleton

hemarthrosis ( J:28436 )

• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal

endocrine/exocrine glands

pancreas cyst ( J:36591 )

• 11% (1 of 9) show pancreatic cyst

liver/biliary system

liver hemorrhage ( J:28436 )

• hepatic subcapsular hematomas developing into fibrotic scars

focal hepatic necrosis ( J:36591 )

• 33% (3 of 9) show necrotic liver foci

immune system

decreased circulating fibrinogen level ( J:28436 )

• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver

• no other abnormal blood parameters

digestive/alimentary system

stomach hemorrhage ( J:36591 )

• 11% (1 of 9) show squamous stomach hemorrhage

integument

subcutaneous hemorrhage ( J:28436 )

• normal at birth

• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal

growth/size/body

pancreas cyst ( J:36591 )

• 11% (1 of 9) show pancreatic cyst

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld Plg^tm1Jld/Plg^tm1Jld
Genetic Background	B6.129P2-Fga^tm1Jld Plg^tm1Jld

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fga^tm1Jld mutation (0 available); any Fga mutation (44 available)
Plg^tm1Jld mutation (2 available); any Plg mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:46096 )

N	• do not develop conjunctivitis as is seen in single Plg homozygotes

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld Plg^tm1Jld/Plg^tm1Jld
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:42819 )

• exhibit resistance to hippocampal neuronal death induced by kainate injection to a similar extent as seen in single Plg homozygotes, suggesting a non-fibrin substrate for plasmin

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld Thbd^tm2Rdr/Thbd^tm2Rdr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fga^tm1Jld mutation (0 available); any Fga mutation (44 available)
Thbd^tm2Rdr mutation (0 available); any Thbd mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:82224 )

• unlike Thbd^tm2Rdr homozygotes which are completely resorbed by E9.5, double homozygotes are recovered as late as E10.5

embryo

embryonic growth arrest ( J:82224 )

• double homozygotes exhibit embryonic growth arrest at E8.5

• inhibition of fibrinolysis with tranexamic acid has the same effect as complete elimination of fibrinogen and results in recovery of growth-arrested embryos at E9.5

small ectoplacental cone ( J:82224 )

• double homozygotes display a proliferation defect in trophoblast cells of the ectoplacental cone

• similarly, inhibition of fibrinolysis with tranexamic acid fails to augment proliferation of ectoplacental trophoblast cells

• in contrast, both the absence of fibrinogen and inhibition of fibrinolysis prevents DNA fragmentation in trophoblast giant cells, as detected by TUNEL assay

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld Vwf^tm1Wgr/Vwf^tm1Wgr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fga^tm1Jld mutation (0 available); any Fga mutation (44 available)
Vwf^tm1Wgr mutation (1 available); any Vwf mutation (140 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:63750 )

• 23% of mice die before weaning

homeostasis/metabolism

abnormal blood coagulation ( J:63750 )

• after FeCl3 treatment, platelet interaction with the vessel wall is delayed and platelet deposition is less than in similarly treated wild-type mice

• thrombi that form in FeCl3-treated mice fail to resist sheer stress and eventually break off unlike in similarly treated wild-type mice

• FeCl3-induced thrombi are more fragile than in similarly treated wild-type mice or Fga^tm1Jld homozygotes

• FeCl3-treated mice exhibit shorter occlusion times compared with similarly treated Vwf^tm1Wgr homozygotes

Allelic Composition	Fga^tm1Jld/Fga^tm1Jld Plg^tm1Jld/Plg^tm1Jld
Genetic Background	involves: 129P2/OlaHsd * Black Swiss * CF-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:36591 )

N	• show rescue from the early morbidity and premature death seen in single Plg homozygotes and show no signs of weight loss or wasting

homeostasis/metabolism

abnormal blood coagulation ( J:36591 )

• shortly after birth, a small fraction of neonates show peritoneal bleeding from which they generally recover, indicating lack of clotting function

• exhibit distinctly larger deposits of dried blood at wound margins and scabs of wounds appear initially less stable than in controls and resumed bleeding is occasionally apparent

abnormal wound healing ( J:36591 )

• exhibit distinctly larger deposits of dried blood at wound margins, however do not exhibit any of the wound healing defects seen in single Plg homozygotes

• scabs of wounds appear initially less stable than in controls and resume bleeding is occasionally apparent

liver/biliary system

abnormal liver morphology ( J:36591 )

• 6% (1 of 17) show hemorrhagic organized liver lesion

• 6% (1 of 17) show dystrophic calcification in liver

focal hepatic necrosis ( J:36591 )

• 41% (7 of 17) show sporadic necrotic liver foci

immune system

immune system phenotype ( J:36591 )

N	• exhibit rescue of the various ulcerations and lesions seen in single Plg homozygotes

digestive/alimentary system

abnormal duodenum morphology ( J:36591 )

• 6% (1 of 17) show dystrophic calcification in duodenum

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