All Phenotypes Col10a1<tm1Ksec> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col10a1^tm1Ksec/Col10a1^tm1Ksec	129/Sv-Col10a1^tm1Ksec	MGI:3849569
hm2	Col10a1^tm1Ksec/Col10a1^tm1Ksec	involves: 129S/SvEv * C57BL/6	MGI:3849570
cx3	Anxa5^tm1Epo/Anxa5^tm1Epo Anxa6^tm1Moss/Anxa6^tm1Moss Col10a1^tm1Ksec/Col10a1^tm1Ksec	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:5696128

Allelic Composition	Col10a1^tm1Ksec/Col10a1^tm1Ksec
Genetic Background	129/Sv-Col10a1^tm1Ksec

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col10a1^tm1Ksec mutation (0 available); any Col10a1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Altered trabecular morphology and organization in the growth plate of Col10a1^tm1Ksec/Col10a1^tm1Ksec mice

skeleton

coxa vara ( J:38124 )

• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)

abnormal long bone epiphyseal plate morphology ( J:38124 )

• at P2, the resting zone of chondrocytes of the growth plate in femurs is reduced 18% to 25% compared to in wild-type mice

• at P2, mice exhibit an increase in the amount of matrix vesicles and proteoglycan-like material in the resting and proliferating zones while the quantity of matrix vesicles and proteoglycan-like material in the upper hypertrophic zone is reduced compared with wild-type mice

decreased bone mineral content ( J:38124 )

• at P2 but not 4 weeks, the femur shaft mineral content is decreased compared with wild-type femurs

• at 4 weeks the mineral content of the femur head is decreased compared with wild-type femurs

abnormal trabecular bone morphology ( J:38124 )

• at P2, the trabecular zone is more compact, has reduced bony material, and has reduced bone marrow space compared to in wild-type mice

• the trabecular zone exhibits increased compaction over time

• Background Sensitivity: alterations in trabecular zone are more obvious than in mice with a mixed background

• mineral distribution in the trabeculae is irregular and patchy compared to in wild-type mice

• at 4 weeks, trabecular bone content is greater than in wild-type mice

limbs/digits/tail

coxa vara ( J:38124 )

• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal femur morphology ( J:193886 )

• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice

coxa vara ( J:38124 )

• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)

decreased bone mineral content ( J:193886 )

• reduce trabecular bone mineral content in female mice at 1 month

• however, mineralization is normal at 1 year

decreased bone mineral density of femur ( J:193886 )

• reduce trabecular bone mineral density in female mice at 1 month

• however, mineralization is normal at 1 year

abnormal trabecular bone morphology ( J:38124 )

• Background Sensitivity: trabecular bone abnormalities are not as obvious as in mcie with a pure 129S/SvEv background

decreased bone mass ( J:38124 )

• at P2 but not 4 weeks, the femur shaft mineral content is decreased compared with wild-type femurs

abnormal cartilage morphology ( J:38124 )

• at 4 weeks, mice exhibit a 17% reduction in articular cartilage thickness compared with wild-type mice

• Background Sensitivity: mice exhibit a greater decrease in articular cartilage thickness compared to mice on a pure 129S/SvEv background

abnormal long bone epiphyseal plate morphology ( J:38124 )

• at P2, the resting zone of chondrocytes of the growth plate in femurs is reduced 18% to 25% compared to in wild-type mice

increased width of hypertrophic chondrocyte zone ( J:193886 )

• in newborn female mice with increased cell numbers

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:193886 )

• isolated naive CD4+ T helper cells are primed to differentiate into T-helper 2 cells

decreased dendritic cell number ( J:193886 )

• decreased CD11c+ dendritic cells at 1 month and 1 year in female mice

increased B cell number ( J:193886 )

• increased percent of CD19+ B cells in the bone marrow at 1 year of age

• increased IgM+/IgD+ naive B cells at 1 year of age

increased T-helper cell number ( J:193886 )

• CD4+/CD8- T-helper cells at 1 month and 1 year in the spleen

limbs/digits/tail

abnormal femur morphology ( J:193886 )

• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice

coxa vara ( J:38124 )

• some mice exhibit coxa vara (a reduction in the angle between the femoral neck and shaft)

immune system

abnormal T-helper 2 cell differentiation ( J:193886 )

• isolated naive CD4+ T helper cells are primed to differentiate into T-helper 2 cells

decreased dendritic cell number ( J:193886 )

• decreased CD11c+ dendritic cells at 1 month and 1 year in female mice

increased B cell number ( J:193886 )

• increased percent of CD19+ B cells in the bone marrow at 1 year of age

• increased IgM+/IgD+ naive B cells at 1 year of age

increased T-helper cell number ( J:193886 )

• CD4+/CD8- T-helper cells at 1 month and 1 year in the spleen

decreased interleukin-10 secretion ( J:193886 )

• phytohaemagglutinin-L (PHA-L)-activated T cells fail to secrete IL10 levels unlike wild-type cells

decreased interleukin-17 secretion ( J:193886 )

• lipopolysaccharide (LPS)-stimulated B cells fail to produce IL17

decreased interleukin-2 secretion ( J:193886 )

• lipopolysaccharide (LPS)-stimulated B cells fail to produce IL2 unlike wild-type cells

• phytohaemagglutinin-L-activated T cells secrete reduced IL2 levels compared with wild-type cells

decreased interleukin-4 secretion ( J:193886 )

• lipopolysaccharide (LPS)-stimulated B cells fail to produce IL4 unlike wild-type cells

increased interleukin-4 secretion ( J:193886 )

• phytohaemagglutinin-L (PHA-L)-activated T cells secrete increased IL4 levels compared with wild-type cells

Allelic Composition	Anxa5^tm1Epo/Anxa5^tm1Epo Anxa6^tm1Moss/Anxa6^tm1Moss Col10a1^tm1Ksec/Col10a1^tm1Ksec
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5^tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
Anxa6^tm1Moss mutation (2 available); any Anxa6 mutation (42 available)
Col10a1^tm1Ksec mutation (0 available); any Col10a1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased dendritic cell number ( J:193886 )

• decreased CD11c+ dendritic cells at 1 year in female mice

increased B cell number ( J:193886 )

• increased percent of CD19+ B cells in the bone marrow at 1 year of age

• increased IgM+/IgD+ naive B cells at 1 year of age

increased T-helper cell number ( J:193886 )

• CD4+/CD8- T-helper cells at 1 year in the spleen

skeleton

abnormal femur morphology ( J:193886 )

• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice

increased width of hypertrophic chondrocyte zone ( J:193886 )

• with increased cell numbers

limbs/digits/tail

abnormal femur morphology ( J:193886 )

• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice

hematopoietic system

decreased dendritic cell number ( J:193886 )

• decreased CD11c+ dendritic cells at 1 year in female mice

increased B cell number ( J:193886 )

• increased percent of CD19+ B cells in the bone marrow at 1 year of age

• increased IgM+/IgD+ naive B cells at 1 year of age

increased T-helper cell number ( J:193886 )

• CD4+/CD8- T-helper cells at 1 year in the spleen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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