Phenotypes associated with this allele

• Allele Symbol: Matn1^tm1Goe
• Allele Name: targeted mutation 1, Paul F Goetinck
• Allele ID: MGI:2153042
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Matn1^tm1Goe/Matn1^tm1Goe	involves: 129S4/SvJae * C57BL/6	MGI:3578136

Genotype
MGI:3578136

hm1

• Allelic Composition: Matn1^tm1Goe/Matn1^tm1Goe
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone epiphyseal plate morphology ( J:58843 )

• exhibit abnormal type II collagen fibrillogenesis and fibril organization in the matrix of the zone of maturation as early as E15 and particularly at P1

• fibrils are bundled in a single direction and show an increase in diameter

• however, do not show disorganization of the chondrocytes of the growth plate, deposition of matrix molecules such as aggrecan or type X collagen, or abnormal skeletal formation