All Phenotypes Sparcl1<tm1Pmc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sparcl1^tm1Pmc
targeted mutation 1, Peter J McKinnon
MGI:2153047

Summary

2 genotypes

Allelic Composition	Sparcl1^tm1Pmc/Sparcl1^tm1Pmc
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sparcl1^tm1Pmc mutation (0 available); any Sparcl1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Abnormal Purkinje cell morphology in the Sparcl1^tm1Pmc/Sparcl1^tm1Pmc and Adamts4^tm1Dqp/Adamts4^tm1Dqp cerebellum

nervous system

abnormal Purkinje cell morphology ( J:159752 )

• mice exhibit stunted and less branched processes extending from extending from Purkinje cell bodies compared to in wild-type mice

gliosis ( J:159752 )

• mice exhibit an increase in glial cells compared to in wild-type mice

Allelic Composition	Sparcl1^tm1Pmc/Sparcl1^tm1Pmc
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sparcl1^tm1Pmc mutation (0 available); any Sparcl1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:59207 )

N	• mice are fertile

nervous system

nervous system phenotype ( J:59207 )

N	• mice exhibit normal brain morphology and astrogliosis reaction following focal mechanical trauma

vision/eye

vision/eye phenotype ( J:59207 )

N	• mice do not develop cataracts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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