All Phenotypes Otx1<tm2(otd)Asim> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845765
cx2	Otx1^tm1Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845768
cx3	Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845769

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:47899 )

• 5% of mice die prior to weaning compared to 30% of Otx1^tm1Asim homozygotes

nervous system

nervous system phenotype ( J:47899 )

N	• telencephalic structural defects observed in Otx1^tm1Asim homozygotes are rescued

abnormal telencephalon development ( J:47899 )

• cell proliferation in the dorsal telencephalon is greater than in Otx1^tm1Asim homozygotes

abnormal cerebellar foliation ( J:47899 )

• in 65% of mice

decreased brain size ( J:47899 )

• 17% of mice exhibit reduced brain size compared with in wild-type mice

decreased brain weight ( J:47899 )

• 17% of mice exhibit a 10% reduction in brain weight compared with wild-type mice

abnormal midbrain morphology ( J:47899 )

• mesencephalic structural defects observed in Otx1^tm1Asim homozygotes are partially rescued

decreased inferior colliculus size ( J:47899 )

• 30% of mice exhibit a 15% reduction in colliculus size compared with wild-type mice

• 50% of mice exhibit an intermediate reduction in colliculus size compared with wild-type mice and Otx1^tm1Asim homozygotes

decreased superior colliculus size ( J:47899 )

• 30% of mice exhibit a 15% reduction in colliculus size compared with wild-type mice

• 50% of mice exhibit an intermediate reduction in colliculus size compared with wild-type mice and Otx1^tm1Asim homozygotes

vision/eye

abnormal eye morphology ( J:47899 )

• 80% of mice exhibit reduced cilliary process and thickened iris compared to in wild-type mice

absent lacrimal glands ( J:47899 )

• in two-thirds of mice

abnormal iris morphology ( J:47899 )

• 80% of mice exhibit thickened iris compared to in wild-type mice

hearing/vestibular/ear

absent lateral semicircular canal ( J:47899 )

behavior/neurological

behavior/neurological phenotype ( J:47899 )

N	• unlike Otx1^tm1Asim homozygotes, mice exhibit moderate-speed turning behavior and lack seizures

endocrine/exocrine glands

absent lacrimal glands ( J:47899 )

• in two-thirds of mice

absent Harderian gland ( J:47899 )

• in two-thirds of mice

Allelic Composition	Otx1^tm1Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm1Asim mutation (2 available); any Otx1 mutation (86 available)
Otx1^tm2(otd)Asim mutation (1 available); any Otx1 mutation (86 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:47899 )

• mice die at birth

nervous system

abnormal brain morphology ( J:47899 )

• mice exhibit abnormal brain morphology

• however, the dorsal thalamus, Ammon's horn, and pretectum absent in Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺ are restored

abnormal midbrain morphology ( J:47899 )

• mice exhibit abnormal mesencephalic morphology with a reduction in thickness of the alar region compared to in wild-type mice

abnormal cerebellum morphology ( J:47899 )

Allelic Composition	Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm2(otd)Asim mutation (1 available); any Otx1 mutation (86 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal midbrain morphology ( J:47899 )

• mice exhibit severe perturbation in the posterior mesencephalon

• however, mice exhibit an improvement in the dorsal thalamus, pretectal area, and anterior mesencephalon morphology compared to in Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺

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