Phenotypes associated with this allele

• Allele Symbol: Otx1^{tm3(OTX2)Asim}
• Allele Name: targeted mutation 3, Antonio Simeone
• Allele ID: MGI:2153200
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx1^tm3(OTX2)Asim/Otx1^tm3(OTX2)Asim	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3845659

Genotype
MGI:3845659

hm1

• Allelic Composition: Otx1^{tm3(OTX2)Asim}/Otx1^{tm3(OTX2)Asim}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:52989 )

N • the postnatal lethality observed in Otx1^tm1Asim homozygotes is rescued

nervous system

nervous system phenotype ( J:52989 )

N • compared to Otx1^tm1Asim homozygotes, the telencephalic cortex is thickened and the regions located dorsally and ventrally to the presumptive sulcus rhinalis are restored to normal size

abnormal telencephalon development ( J:52989 )

• cell proliferation in the dorsal telencephalon is greater than in Otx1^tm1Asim homozygotes

abnormal cerebellar foliation ( J:52989 )

• in 50% of mice

decreased brain size ( J:52989 )

• mice exhibit reduced brain size compared with wild-type mice that is not as severe as in Otx1^tm1Asim homozygotes

decreased brain weight ( J:52989 )

• mice exhibit reduced brain mass compared with wild-type mice that is not as severe as in Otx1^tm1Asim homozygotes

decreased midbrain size ( J:52989 )

• 45% of mice exhibit a reduction in mesencephalon size compared to in wild-type mice

hearing/vestibular/ear

abnormal inner ear morphology ( J:52989 )

• mice exhibit a partial rescue of inner ear defects observed in Otx1^tm1Asim homozygotes

absent lateral semicircular canal ( J:52989 )

vision/eye

absent lacrimal glands ( J:52989 )

• in 25% of mice

absent ciliary process ( J:52989 )

• 30% of mice lack the ciliary process

behavior/neurological

behavior/neurological phenotype ( J:52989 )

N • unlike Otx1^tm1Asim homozygotes, mice exhibit moderate-speed turning behavior and lack seizures

endocrine/exocrine glands

absent lacrimal glands ( J:52989 )

• in 25% of mice

absent Harderian gland ( J:52989 )

• in 25% of mice