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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm3Jrt
targeted mutation 3, Janet Rossant
MGI:2153345
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfr1tm3Jrt/Fgfr1tm3Jrt involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2181566


Genotype
MGI:2181566
hm1
Allelic
Composition		 Fgfr1tm3Jrt/Fgfr1tm3Jrt
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3Jrt mutation (0 available); any Fgfr1 mutation (223 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:49154 )
• a number of homozygous mutant embryos are found dead or resorbed at E9.5

embryo
abnormal gastrulation ( J:49154 )
• at E9.5, homozygotes display a gastrulation defect
decreased paraxial mesoderm size ( J:49154 )
• at E9.5, homozygotes exhibit a significantly reduced paraxial mesoderm
abnormal somite development ( J:49154 )
• at E9.5, paraxial mesoderm is not organized into somites
absent somites ( J:49154 )
• at E9.5, homozygotes show absence of somite formation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory