All Phenotypes Fgfr1<tm6.1Jrt> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgfr1^tm6.1Jrt
targeted mutation 6.1, Janet Rossant
MGI:2153352

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr1^tm6.1Jrt/Fgfr1^tm6.1Jrt	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2181574
ht2	Fgfr1^tm1Jrt/Fgfr1^tm6.1Jrt	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2181575
cn3	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm6.1Jrt/Fgfr1^tm1Jpa	involves: 129	MGI:6116894

Allelic Composition	Fgfr1^tm6.1Jrt/Fgfr1^tm6.1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm6.1Jrt mutation (0 available); any Fgfr1 mutation (223 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:49154 )

abnormal sternocostal joint morphology ( J:49154 )

• R7 (45%) is not attached to the sternum of newborn mice

rib fusion ( J:49154 )

• rib fusion (21%) occurs in newborn mice

abnormal vertebrae morphology ( J:49154 )

• vertebral transformations to posterior direction

• however, the number of caudal vertebrae is not reduced

thoracic vertebral transformation ( J:49154 )

• transformations of T1 to T2 (9.1%), T12 to L1 (4.5%), and T13 to L1 (55%)

cervical vertebral transformation ( J:49154 )

• transformations of C5 to C6 (9.1%), C6 to C7 (13.6%), and C7 to T1 (59%)

lumbar vertebral transformation ( J:49154 )

• transformation of L5 to S1 (4.5%) and L6 to S1 (73%)

sacral vertebral transformation ( J:49154 )

• transformation of S1 to S2 (59%) and S3 to S4 (23%)

Allelic Composition	Fgfr1^tm1Jrt/Fgfr1^tm6.1Jrt
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jrt mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1^tm6.1Jrt mutation (0 available); any Fgfr1 mutation (223 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:49154 )

rib fusion ( J:49154 )

• rib (27%) fusion occurs in newborn mice

abnormal vertebrae morphology ( J:49154 )

• vertebral transformations to posterior direction

• however, the number of caudal vertebrae is not reduced

thoracic vertebral transformation ( J:49154 )

• transformations of T1 to T2 (11%), T12 to L1 (44%), and T13 to L1 (11%)

cervical vertebral transformation ( J:49154 )

• transformations of C5 to C6 (22%), C6 to C7 (11%), and C7 to T1 (44%)

lumbar vertebral transformation ( J:49154 )

• transformations of L5 to S1 (11%) and L6 to S1 (55%)

sacral vertebral transformation ( J:49154 )

• transformations of S1 to S2 (44%) and S3 to S4 (28%)

Allelic Composition	Fgfr2^tm1Dor/Fgfr2^tm1Dor Fgfr3^tm6.1Cxd/Fgfr3^tm6.1Cxd Foxg1^tm1(cre)Skm/Foxg1⁺ Fgfr1^tm6.1Jrt/Fgfr1^tm1Jpa
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1^tm6.1Jrt mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3^tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:242687 )

N	• brain morphology at E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24