All Phenotypes Tyr<c-26DVT> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyr^c-26DVT/Tyr^c-26DVT	involves: 101/Rl * C3H/Rl * T-stock	MGI:3818691
ht2	Tyr^c-26DVT/Tyr⁺	involves: 101/Rl * C3H/Rl * T-stock	MGI:5293748
ht3	Tyr^c/Tyr^c-26DVT	involves: 101/Rl * C3H/Rl * T-stock	MGI:5293749
cx4	Tenm4^l7Rn3-4R/Tyr^c-26DVT	involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock	MGI:3789295

Allelic Composition	Tyr^c-26DVT/Tyr^c-26DVT
Genetic Background	involves: 101/Rl * C3H/Rl * T-stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-26DVT mutation (2 available); any Tyr mutation (378 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:23420 , J:100221 , J:141526 )

Allelic Composition	Tyr^c-26DVT/Tyr⁺
Genetic Background	involves: 101/Rl * C3H/Rl * T-stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-26DVT mutation (2 available); any Tyr mutation (378 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:100221 )

Allelic Composition	Tyr^c/Tyr^c-26DVT
Genetic Background	involves: 101/Rl * C3H/Rl * T-stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c mutation (80 available); any Tyr mutation (378 available)
Tyr^c-26DVT mutation (2 available); any Tyr mutation (378 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

absent coat pigmentation ( J:100221 )

pigmentation

absent coat pigmentation ( J:100221 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:96673 )

N	• when the Odz4^l7Rn3-4R allele is inherited from the father, animals survive to adulthood

prenatal lethality, complete penetrance ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, animals die as embryos between E8.5 and E17.5

cardiovascular system

abnormal vasculogenesis ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, defects in vascularization are seen

embryo

embryonic growth retardation ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, developmental delay is seen

abnormal limb bud morphology ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, abnormalities in limb bud elongation are seen

kinked neural tube ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, kinky neural tubes are observed

growth/size/body

embryonic growth retardation ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, developmental delay is seen

decreased body size ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, 30% of animals appear runted and scruffy at weaning

limbs/digits/tail

abnormal limb bud morphology ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, abnormalities in limb bud elongation are seen

nervous system

kinked neural tube ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, kinky neural tubes are observed

skeleton

thoracic vertebral fusion ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, 27% of mutant animals display lumbar and/or thoracic vertebral fusions

abnormal cervical axis morphology ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, an aberrant spinous process is observed in 18% of mutant animals

lumbar vertebral fusion ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, 27% of mutant animals display lumbar and/or thoracic vertebral fusions

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