Phenotypes associated with this allele

• Allele Symbol: Fgfr2^tm1Lni
• Allele Name: targeted mutation 1, Peter Lonai
• Allele ID: MGI:2153799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^tm1Lni/Fgfr2^tm1Lni	involves: 129S1/Sv * 129X1/SvJ * MF1	MGI:2176479

Genotype
MGI:2176479

hm1

• Allelic Composition: Fgfr2^tm1Lni/Fgfr2^tm1Lni
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:47643 )

• homozygous mutant embryos die a few hours after implantation

embryo

embryo phenotype ( J:47643 )

N • homozygotes exhibit normal preimplantation development up to the blastocyst stage

abnormal developmental patterning ( J:47643 )

• homozygotes show random positioning within the uterine crypt

• mutant embryos attach to the uterine epithelium but, instead of the normal mesometrial position of the inner cell mass (ICM), they adhere to the side or to the antimesometrial end of the crypt

abnormal endoderm development ( J:47643 )

• homozygotes exhibit defective ICM differentiation into the primitive endoderm and its derivative, the visceral endoderm

absent primitive endoderm ( J:47643 )

• homozygotes lack the layer of primitive endoderm cells that normally faces the yolk cavity in wild-type embryos

abnormal egg cylinder morphology ( J:47643 )

• in vitro, mutant blastocysts hatch, adhere, and form a layer of trophoblast giant cells; however, after prolonged culture, the ICM ceases to grow, no visceral endoderm forms, and the egg cylinder disintegrates

absent blastocoele ( J:47643 )

• mutant embryos display absence of the former blastocele

inner cell mass degeneration ( J:47643 )

• in some homozygous mutant embryos, the ICM disaggregates soon after implantation

abnormal decidualization ( J:47643 )

♀ • homozygotes exhibit incomplete trophectoderm-induced decidualization

♀ • mutant blastocysts induce increased capillary permeability but fail to complete a normal uterine reaction

reproductive system

abnormal decidualization ( J:47643 )

♀ • homozygotes exhibit incomplete trophectoderm-induced decidualization

♀ • mutant blastocysts induce increased capillary permeability but fail to complete a normal uterine reaction