All Phenotypes Fgfr2<tm1Dsn> MGI Mouse

increased incidence of tumors by chemical induction ( J:119723 )

• DMBA and TPA treated mice develop papillomas within 8 weeks compared to 3 months in mice treated with TPA alone or 34 weeks in similarly treated wild-type mice

• mice treated with DMBA develop squamous cell carcinomas from existing papillomas

increased skin papilloma incidence ( J:119723 )

• in 10% of mice older than 8 months, hyperthickened and keratinized papillomas form in regions of mechanical stress unlike in wild-type mice

adipose tissue inflammation ( J:119723 )

• unlike in wild-type mice, macrophages infiltrate into the adipose tissue

increased gamma-delta T cell number ( J:119723 )

• 38% increase in the epidermis

skin inflammation ( J:119723 )

• unlike in wild-type mice, macrophages infiltrate into the dermis

• the number of gamma-delta T cells is increased 38% in the epidermis compared to in wild-type mice

increased incidence of tumors by chemical induction ( J:119723 )

• DMBA and TPA treated mice develop papillomas within 8 weeks compared to 3 months in mice treated with TPA alone or 34 weeks in similarly treated wild-type mice

• mice treated with DMBA develop squamous cell carcinomas from existing papillomas

increased gamma-delta T cell number ( J:119723 )

• 38% increase in the epidermis

adipose tissue inflammation ( J:119723 )

• unlike in wild-type mice, macrophages infiltrate into the adipose tissue

increased keratinocyte proliferation ( J:119723 )

• in the tails of older mice and nipples of younger virgin females

sebaceous gland atrophy ( J:119723 )

• after P6, sebaceous glands atrophy and are absent by 3 months

skin inflammation ( J:119723 )

• unlike in wild-type mice, macrophages infiltrate into the dermis

• the number of gamma-delta T cells is increased 38% in the epidermis compared to in wild-type mice

abnormal zigzag hair morphology ( J:119723 )

• disorganized structure and thin

abnormal nail morphology ( J:119723 )

• long claws

abnormal hair follicle morphology ( J:119723 )

• disorganized structure

abnormal hair follicle orientation ( J:119723 )

• at P16, many follicles extend down beneath the dermis with some reaching to the muscle layer at the base of the adipose tissue unlike in wild-type mice

abnormal hair cycle ( J:119723 )

• the first wave of hair follicle cycling is asynchronous unlike in wild-type mice

abnormal epidermal layer morphology ( J:119723 )

epidermal cyst ( J:119723 )

• in the nipples of younger virgin females

parakeratosis ( J:119723 )

thick epidermis ( J:119723 )