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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighatm2Grh
targeted mutation 2, Gregory Harriman
MGI:2154386
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighatm2Grh/Ighatm2Grh involves: 129S7/SvEvBrd * C57BL/6 MGI:3845666


Genotype
MGI:3845666
hm1
Allelic
Composition		 Ighatm2Grh/Ighatm2Grh
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighatm2Grh mutation (0 available); any Igha mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:72521 )
• B cells cultured with LPS produce levels of IgA that are almost 10-fold higher than controls
• the IgA levels approach those seen when wild-type B cells are activated in the presence of LPS and TGF-beta
• surface IgA expression is also enhanced by LPS compared to controls

hematopoietic system
abnormal class switch recombination ( J:72521 )
• B cells cultured with LPS produce levels of IgA that are almost 10-fold higher than controls
• the IgA levels approach those seen when wild-type B cells are activated in the presence of LPS and TGF-beta
• surface IgA expression is also enhanced by LPS compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory