Phenotypes associated with this allele

• Allele Symbol: Cacna1a^rkr
• Allele Name: rocker
• Allele ID: MGI:2154404
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1a^rkr/Cacna1a^rkr	B6.Cg-Cacna1a^rkr	MGI:2174919

Genotype
MGI:2174919

hm1

• Allelic Composition: Cacna1a^rkr/Cacna1a^rkr
• Genetic Background: B6.Cg-Cacna1a^rkr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:71860 )

• action tremor at 3-4 weeks of age

abnormal locomotor coordination ( J:71860 )

ataxia ( J:71860 )

• onset at P21-28

abnormal gait ( J:71860 )

• ataxic gait initiated by an action tremor at 3-4 weeks of age, however do not display paroxysmal dyskinesia

• splayed stance of hindlimbs and clumsy, uncoordinated behavior, especially on uneven surfaces

absence seizures ( J:71860 )

• spontaneous appearance of bilaterally synchronous and symmetrical 6-7 Hz spike-wave discharges while awake

• episodes occur at a mean frequency range of 41-65 episodes per hour and a mean burst duration of 1-1.7 sec

nervous system

absence seizures ( J:71860 )

• spontaneous appearance of bilaterally synchronous and symmetrical 6-7 Hz spike-wave discharges while awake

• episodes occur at a mean frequency range of 41-65 episodes per hour and a mean burst duration of 1-1.7 sec

abnormal Purkinje cell dendrite morphology ( J:71860 )

• Purkinje cell arbor is reduced in dendritic mass and complexity in mice over 1 year of age

• abnormal secondary outgrowth of the tips of the distal dendrites

• shafts of main Purkinje dendrites show a thickening in the upper molecular layer