Analysis Tools
mortality/aging
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• an additional 45% die around weaning
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• surviving adults rarely survive beyond 18 weeks of age
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• about 30% die within 48 hours of birth
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endocrine/exocrine glands
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• marked decrease of acidophilic lactotroph cells
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• marked decrease of acidophilic somatotroph cells
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• about 1/3 normal size
• posterior and intermediate lobes of normal size
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• growth hormone levels in pituitary about 1/20 normal
• prolactin and luteinizing hormone levels also considerably reduced
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• estradiol undetectable
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• testosterone undetectable
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vision/eye
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• eye opening delayed 2-3 days
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growth/size/body
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• marked growth retardation from 2 weeks of age onward
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• about 25% of normal weight at 8 weeks of age
• juvenile body proportions
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behavior/neurological
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• cold sensitive by 8 weeks of age
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craniofacial
reproductive system
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• estradiol undetectable
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• testosterone undetectable
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infertility
(
J:31764
)
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• both sexes are sexually infantile
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immune system
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• about 1/5 the number in controls
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• 5-10 fold reduction in the number of polymorphonuclear neutrophiles
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• 5-10 fold reduction in the numbers of lymphocytes
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skeleton
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• decreased width of the endochondral ossification zone
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hematopoietic system
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• about 1/5 the number in controls
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• 5-10 fold reduction in the number of polymorphonuclear neutrophiles
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• 5-10 fold reduction in the numbers of lymphocytes
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nervous system
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• marked decrease of acidophilic lactotroph cells
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• marked decrease of acidophilic somatotroph cells
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• about 1/3 normal size
• posterior and intermediate lobes of normal size
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• growth hormone levels in pituitary about 1/20 normal
• prolactin and luteinizing hormone levels also considerably reduced
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• no growth hormone releasing hormone in the arcuate nucleus of the hypothalamus but normal production in the ventromedial nucleus
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