Phenotypes associated with this allele

• Allele Symbol: Sle1c^NZM2410/J
• Allele Name: NZM2410/J
• Allele ID: MGI:2154453
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sle1c^NZM2410/J/Sle1c^NZM2410/J	involves: C57BL/6J * NZM2410/J	MGI:2175302
ht2	Sle1c^NZB/Sle1c^NZM2410/J	involves: C57BL/6J * NZB * NZM2410/J	MGI:3844991
ht3	Sle1c^C57BL/6J/Sle1c^NZM2410/J	involves: C57BL/6J * NZM2410/J	MGI:2677495

Genotype
MGI:2175302

hm1

• Allelic Composition: Sle1c^NZM2410/J/Sle1c^NZM2410/J
• Genetic Background: involves: C57BL/6J * NZM2410/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased anti-chromatin antibody level ( J:67544 )

• increased anti-chromatin antibody production

Genotype
MGI:3844991

ht2

• Allelic Composition: Sle1c^NZB/Sle1c^NZM2410/J
• Genetic Background: involves: C57BL/6J * NZB * NZM2410/J

immune system

increased autoantibody level ( J:145133 )

♀ • increased anti-chromatin and anti-dsDNA antibody titers in females

♀ • accelerated onset of autoantibody production in females

glomerulonephritis ( J:145133 )

♀ • increased levels of C3 and IgG immune complex glomerular deposits in females

♀ • increased renal histology and proliferative glomerulonephritis in females

renal/urinary system

glomerulonephritis ( J:145133 )

♀ • increased levels of C3 and IgG immune complex glomerular deposits in females

♀ • increased renal histology and proliferative glomerulonephritis in females

renal glomerular immunoglobulin deposits ( J:145133 )

♀ • increased levels of C3 and IgG immune complex glomerular deposits in females

Genotype
MGI:2677495

ht3

• Allelic Composition: Sle1c^C57BL/6J/Sle1c^NZM2410/J
• Genetic Background: involves: C57BL/6J * NZM2410/J

immune system

increased anti-chromatin antibody level ( J:67544 )

• increased anti-chromatin antibody production