All Phenotypes Cdx1<tm1Pgr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdx1^tm1Pgr
targeted mutation 1, Peter Gruss
MGI:2154514

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdx1^tm1Pgr/Cdx1^tm1Pgr	involves: 129 * C57BL/6	MGI:3817892
hm2	Cdx1^tm1Pgr/Cdx1^tm1Pgr	involves: 129S1/Sv * 129X1/SvJ	MGI:2662512
hm3	Cdx1^tm1Pgr/Cdx1^tm1Pgr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2662509
hm4	Cdx1^tm1Pgr/Cdx1^tm1Pgr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:2180351
hm5	Cdx1^tm1Pgr/Cdx1^tm1Pgr	involves: 129S1/Sv * 129X1/SvJ * NMRI	MGI:2662505
ht6	Cdx1^tm1Pgr/Cdx1⁺	involves: 129 * C57BL/6	MGI:3817890
ht7	Cdx1^tm1Lhn/Cdx1^tm1Pgr	involves: 129 * C57BL/6	MGI:3817893
cn8	Cdx1^tm1Pgr/Cdx1^tm1Pgr Cdx2^tm2Fbe/Cdx2^tm2Fbe Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129 * C57BL/6 * CBA	MGI:5308974
cn9	Cdx1^tm1Pgr/Cdx1^tm1Pgr Gt(ROSA)26Sor^{tm1(en/Cdx1,-EGFP)Npln}/Gt(ROSA)26Sor⁺ Tg(Pax3-cre)1Joe/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5774471
cx10	Cdx1^tm1Pgr/Cdx1⁺ Rarg^tm1Ipc/Rarg^tm1Ipc	involves: 129 * C57BL/6	MGI:3817898
cx11	Cdx1^tm1Pgr/Cdx1^tm1Pgr Cdx4^tm1.1Jdes/Y	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613764

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:86514 )

absent ribs ( J:86514 )

• 38% of mice are missing a rib on vertebrae 8

rib fusion ( J:86514 )

• 62% of mice have a fused rib on vertebrae 8

abnormal ventral tubercle of atlas morphology ( J:86514 )

• 100% of mice have anterior tubercles that have shifted posteriorly to the seventh cervical vertebrae

cervical vertebral transformation ( J:86514 )

• 100% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 100% of mice have thick neural arches in the vertebrae

abnormal vertebral spinous process morphology ( J:86514 )

• 54% of mice have posterior spinous processes on V10 and sometimes V9

fusion of vertebral arches ( J:86514 )

• 14% of mice have neural arch fusions of V1 to V4

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

rib fusion ( J:29755 )

• R1 and R2 are fused unilaterally in 28% and bilaterally in 35% of mice

vertebral transformation ( J:29755 )

• anterior homeotic transformation of vertebrae, with the first vertebra developing into a more anterior structure, the basioccipital bone, and subsequent vertebrae up to the posterior thoracic ones assuming anterior identities; penetrance varies somewhat with background

craniofacial

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

embryo

abnormal embryonic erythropoiesis ( J:136405 )

• hematopoietic progenitor formation is reduced in cells derived from day 6 erythroid bodies

• but no impairment in yolk sac hematopoiesis is detected

hematopoietic system

abnormal embryonic erythropoiesis ( J:136405 )

• hematopoietic progenitor formation is reduced in cells derived from day 6 erythroid bodies

• but no impairment in yolk sac hematopoiesis is detected

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

rib fusion ( J:29755 )

• R1 and R2 are fused unilaterally in 6% and bilaterally in 6% of mice

vertebral transformation ( J:29755 )

craniofacial

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased rib number ( J:104372 )

• thoracic to cervical transformation of V8, with the consequent loss of one rib

thoracic vertebral transformation ( J:104372 )

• 5 of 9 have their first rib on the 9th vertebrae (V9) unilaterally instead of on V8 (thoracic to cervical transformation of V8, with the consequent loss of one rib)

• 2 of 9 have the 8th rib pair attached to the sternum bilaterally and 3 of 9 have the 8th rib pair attached to the sternum unilaterally, indicating anterior transformation at the level of V15

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

rib fusion ( J:29755 )

• R1 and R2 are fused unilaterally in 40% and bilaterally in 28% of mice

vertebral transformation ( J:29755 )

craniofacial

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

Allelic Composition	Cdx1^tm1Pgr/Cdx1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

cervical vertebral transformation ( J:86514 )

• 56% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

fusion of vertebral arches ( J:86514 )

• 26% of mice have neural arch fusions of V1 to V4

Allelic Composition	Cdx1^tm1Lhn/Cdx1^tm1Pgr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Lhn mutation (0 available); any Cdx1 mutation (13 available)
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

rib fusion ( J:86514 )

• a fused rib occurred on vertebrae 8 in one mouse out of a group of 15

abnormal ventral tubercle of atlas morphology ( J:86514 )

• 33% of mice have anterior tubercles that have shifted posteriorly to the seventh cervical vertebrae

cervical vertebral transformation ( J:86514 )

• 33% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 33% of mice have thick neural arches in the vertebrae

abnormal vertebral spinous process morphology ( J:86514 )

• 20% of mice have posterior spinous processes on V10 and sometimes V9

fusion of vertebral arches ( J:86514 )

• 33% of mice have neural arch fusions of V1 to V4

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr Cdx2^tm2Fbe/Cdx2^tm2Fbe Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Cdx2^tm2Fbe mutation (0 available); any Cdx2 mutation (22 available)
Tg(Cyp1a1-cre/ERT)1Dwi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:179732 )

• cystic vesicles appear 1 week after treatment with tamoxifen and BNF, earlier than in mutant mice wild-type for Cdx1

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:179732 )

• cystic vesicles appear 1 week after treatment with tamoxifen and BNF, earlier than in mutant mice wild-type for Cdx1

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr Gt(ROSA)26Sor^{tm1(en/Cdx1,-EGFP)Npln}/Gt(ROSA)26Sor⁺ Tg(Pax3-cre)1Joe/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Gt(ROSA)26Sor^{tm1(en/Cdx1,-EGFP)Npln} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pax3-cre)1Joe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal melanoblast migration ( J:231654 )

• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants

embryo

abnormal melanoblast migration ( J:231654 )

• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants

integument

white spotting ( J:231654 )

• increase in penetrance and extent of white spotting in the posterior regions

belly spot ( J:231654 )

nervous system

abnormal hypoglossal nerve morphology ( J:231654 )

• E10.5 mutants exhibit abnormalities of the hypoglossal nerve, with the converging roots appearing disorganized and less dense and resulting in a reduced number of elongating axons that are shorter

fused dorsal root ganglion ( J:231654 )

• E10.5 embryos exhibit the presence of fusions of dorsal root ganglia in the cervical region

pigmentation

white spotting ( J:231654 )

• increase in penetrance and extent of white spotting in the posterior regions

belly spot ( J:231654 )

Allelic Composition	Cdx1^tm1Pgr/Cdx1⁺ Rarg^tm1Ipc/Rarg^tm1Ipc
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Rarg^tm1Ipc mutation (1 available); any Rarg mutation (151 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

cervical vertebral transformation ( J:86514 )

• 90% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2

abnormal vertebral arch morphology ( J:86514 )

• 60% of mice have thick neural arches in the vertebrae

abnormal vertebral spinous process morphology ( J:86514 )

• 30% of mice have posterior spinous processes on V10 and sometimes V9

fusion of vertebral arches ( J:86514 )

• 40% of mice have neural arch fusions of V1 to V4

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr Cdx4^tm1.1Jdes/Y
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Cdx4^tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased rib number ( J:104372 )

• thoracic to cervical transformation of V8, with the consequent loss of one rib

thoracic vertebral transformation ( J:104372 )

• 5 of 7 have their first rib on the 9th vertebrae (V9) instead of on V8 (thoracic to cervical transformation of V8, with the consequent loss of one rib), with 3 of 5 exhibiting this transformation bilaterally

• 5 of 7 have the 8th rib pair attached to the sternum bilaterally, indicating anterior transformation at the level of V15

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