Analysis Tools|
Allele Symbol Allele Name Allele ID |
Smarcc1tm1Rhs targeted mutation 1, Rho H Seong MGI:2154523 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die at the peri-implantation stage; embryos undergo normal hatching and partial outgrowth in culture
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• no visible endoderm layer
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• a few dispersed cells were noted
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region
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• extensive malformations in embryos exhibiting exencephaly; expansion of the corpus striatum mediale
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• described as malformed
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• open third ventricle
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• epithelia were located below the thalamus; ganglionic eminence appeared rotated towards the midline
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• stenosis apparent
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• 20% of heterozygous embryos exhibit exencephaly
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• in some embryos exhibit failure of neural fold elevation resulting in failure of neural plate closing and an abnormal brain structure
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• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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