Analysis Tools|
Allele Symbol Allele Name Allele ID |
Smarcc1tm1Rhs targeted mutation 1, Rho H Seong MGI:2154523 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• embryos die at the peri-implantation stage; embryos undergo normal hatching and partial outgrowth in culture
|
|
• no visible endoderm layer
|
|
• a few dispersed cells were noted
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region
|
|
• extensive malformations in embryos exhibiting exencephaly; expansion of the corpus striatum mediale
|
|
• described as malformed
|
|
• open third ventricle
|
|
• epithelia were located below the thalamus; ganglionic eminence appeared rotated towards the midline
|
|
• stenosis apparent
|
|
• 20% of heterozygous embryos exhibit exencephaly
|
|
• in some embryos exhibit failure of neural fold elevation resulting in failure of neural plate closing and an abnormal brain structure
|
|
• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
