Phenotypes associated with this allele

• Allele Symbol: App^tm2Cwe
• Allele Name: targeted mutation 2, Charles Weissmann
• Allele ID: MGI:2154535
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm2Cwe/App^tm2Cwe	involves: 129P2/OlaHsd * 129S/SvEv	MGI:2176996
hm2	App^tm2Cwe/App^tm2Cwe	involves: 129P2/OlaHsd * C57BL/6	MGI:3590206
ht3	App^tm3.2Umu/App^tm2Cwe	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N	MGI:4822179
cx4	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2Cwe/App^tm2Cwe	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:2176994
cx5	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:2176990

Genotype
MGI:2176996

hm1

• Allelic Composition: App^tm2Cwe/App^tm2Cwe
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:54584 )

• brain weight is reduced 10% relative to controls

abnormal brain commissure morphology ( J:54584 )

absent corpus callosum ( J:54584 )

• Background Sensitivity: greatly increased frequency of absent corpus callosum over controls in 129-derived genetic backgrounds

decreased hippocampal commissure size ( J:54584 )

• Background Sensitivity: greatly reduced ventral hippocampal commissure; 83% reduced compared to controls

decreased anterior commissure size ( J:54584 )

• reduced size of anterior commissure, independent of genetic background

Genotype
MGI:3590206

hm2

• Allelic Composition: App^tm2Cwe/App^tm2Cwe
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

decreased brain weight ( J:54584 )

• brain weight is reduced 10% relative to controls

abnormal brain commissure morphology ( J:54584 )

decreased corpus callosum size ( J:54584 )

• Background Sensitivity: 4-11% smaller than controls; absence of corpus callosum is not statistically significant in mutant lines with greater than 50% C57BL/6 genetic background contribution when compared to controls

decreased hippocampal commissure size ( J:54584 )

• Background Sensitivity: reduced ventral hippocampal commissure; comparable to the size reduction in App^tm1Cwe mutant mice on a mixed C57BL/6 and 129S2/SvPas genetic background

Genotype
MGI:4822179

ht3

• Allelic Composition: App^tm3.2Umu/App^tm2Cwe
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

behavior/neurological

decreased grip strength ( J:163059 )

• displayed a pronounced and significant difference in grip strength compared to wild-type mice

growth/size/body

decreased body weight ( J:163059 )

• body weight is reduced by about 10.6%

nervous system

decreased brain weight ( J:163059 )

• wet brain weight is reduced

Genotype
MGI:2176994

cx4

• Allelic Composition: Aplp2^tm1Dbo/Aplp2^tm1Dbo; App^tm2Cwe/App^tm2Cwe
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:65196 )

• no defect detected grossly or microscopically

• no animals survive to weaning age

Genotype
MGI:2176990

cx5

• Allelic Composition: Aplp1^tm1Umu/Aplp1^tm1Umu; App^tm2Cwe/App^tm2Cwe
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

growth/size/body

decreased body weight ( J:65196 )

• 10% decrease in body weight at 9 weeks of age