Phenotypes associated with this allele

• Allele Symbol: Tnr^tm1Msch
• Allele Name: targeted mutation 1, Melitta Schachner
• Allele ID: MGI:2154583
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnr^tm1Msch/Tnr^tm1Msch	involves: 129P2/OlaHsd * C57BL/6J	MGI:2655920

Genotype
MGI:2655920

hm1

• Allelic Composition: Tnr^tm1Msch/Tnr^tm1Msch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:55338 )

• abnormal distribution and shape of perineuronal nets of GABAergic interneurons

• altered distribution of the extracellular matrix component, phosphacan, a chondroitin sulfate proteoglycan, in the retina, optic nerve, and spinal cord

• however, mutants exhibit normal myelination, nodes of Ranvier, and Na+ channel density

abnormal hippocampus CA1 region morphology ( J:81471 )

• structural alterations of perisomatic synapses in the CA1 region

• coverage of the plasma membrane of pyramidal cell bodies by active zones of symmetric synapses is reduced by at least 40%

• length of active zone profiles of perisomatic inhibitory synapses in the CA1 pyramidal cell layer is 8-14% smaller, whereas the number of active zones per length unit of cell body is 30-40% smaller

abnormal hippocampus pyramidal cell layer ( J:81471 )

• mutants exhibit a reduction in density of and a more diffuse and disordered spatial arrangement of pyramidal neurons in the CA1 pyramidal cell layer than wild-type mice

• reduction in coverage of CA1 pyramidal neurons by terminals forming symmetric synapses

abnormal synapse morphology ( J:81471 )

• perisomatic synapses in the CA1 region show shorter active zone profiles and increased numbers of and abnormal arrangement of synaptic vesicles

abnormal synaptic vesicle number ( J:81471 )

• density of synaptic vesicles is higher in the perisomatic synapses of the CA1 region of mutants than in wild-type mice

decreased nerve conduction velocity ( J:55338 )

• conduction velocity in the optic nerve is decreased