All Phenotypes Cd3e<tm1Mal> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd3e^tm1Mal
targeted mutation 1, Bernard Malissen
MGI:2155092

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd3e^tm1Mal/Cd3e^tm1Mal	C57BL/6-Cd3e^tm1Mal	MGI:3759843
hm2	Cd3e^tm1Mal/Cd3e^tm1Mal	involves: C57BL/6	MGI:2653630
cx3	Cd3e^tm1Mal/Cd3e^tm1Mal Lat^tm1.1Mal/Lat^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:3770646
cx4	Cd3e^tm1Mal/Cd3e^tm1Mal Tg(Tcrb-TCF3/PBX1)23Gusa/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:5638106
cx5	Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1	involves: C57BL/6	MGI:5474289

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal
Genetic Background	C57BL/6-Cd3e^tm1Mal

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125748 )

• mice die of a wasting autoimmune disease starting 15 weeks after transfer of nave wild-type CD4 T cells

immune system

abnormal double-negative T cell morphology ( J:81133 )

• proportion of and absolute number of CD117++ double negative (CD44+CD25-) cells among thymocytes is reduced

arrested T cell differentiation ( J:81133 )

• severe block in T cell development

absent T cells ( J:131351 )

• T cells are absent in these mice

abnormal B cell morphology ( J:81133 )

• with increasing age, the number of thymic B cells remains constant, however proportion of pro/pre-B cells is decreased with time

abnormal regulatory T cell physiology ( J:125748 )

• mice exhibit symptoms of an autoimmune disorder starting 12 weeks after transfer of nave wild-type CD4 T Cells

• however, mice fail to develop signs of wasting disease after transfer of wild-type CD25-positive CD4 T cells

hematopoietic system

abnormal double-negative T cell morphology ( J:81133 )

• proportion of and absolute number of CD117++ double negative (CD44+CD25-) cells among thymocytes is reduced

arrested T cell differentiation ( J:81133 )

• severe block in T cell development

absent T cells ( J:131351 )

• T cells are absent in these mice

abnormal B cell morphology ( J:81133 )

• with increasing age, the number of thymic B cells remains constant, however proportion of pro/pre-B cells is decreased with time

abnormal regulatory T cell physiology ( J:125748 )

• mice exhibit symptoms of an autoimmune disorder starting 12 weeks after transfer of nave wild-type CD4 T Cells

• however, mice fail to develop signs of wasting disease after transfer of wild-type CD25-positive CD4 T cells

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

hematopoietic system

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Lat^tm1.1Mal/Lat^tm1.1Mal
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (54 available)
Lat^tm1.1Mal mutation (0 available); any Lat mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:77098 )

N	• pathological B cells of Lat^tm1Mal homozygotes are absent in these mice

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

hematopoietic system

arrested T cell differentiation ( J:77098 )

• T cells are arrested at the double negative stage

absent CD4-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

absent CD8-positive, alpha-beta T cells ( J:77098 )

• in both the thymus and spleen

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Tg(Tcrb-TCF3/PBX1)23Gusa/0
Genetic Background	involves: C3H * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (54 available)
Tg(Tcrb-TCF3/PBX1)23Gusa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:95693 )

• leukemia tumor development penetrance is 87%

• mice intraperitonally injected with MMLV show accelerated pre-B-cell leukemia formation compared to controls

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 40% of mice develop B-cell acute lymphoblastic leukemia

• however, mice do not develop T-cell acute lymphoblastic leukemia, myeloid leukemia, or mixed B-cell/myeloid leukemia

• B-cell leukemia development is accelerated compared to single Tg(Tcrb-TCF3/PBX1)23Gusa transgenic mice

• B-cell tumors are B220+/CD43-/CD19+/IgM-/Pax5+, indicating a pre-B-cell phenotype, and contain IgH chain rearrangements, mostly of the kappa light chain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute leukemia		DOID:12603	OMIM:308960	J:95693

Allelic Composition	Cd3e^tm1Mal/Cd3e^tm1Mal Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1Mal mutation (4 available); any Cd3e mutation (54 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased neutrophil cell number ( J:191055 )

skin inflammation ( J:191055 )

• neutrophil infiltration of the dermis

increased susceptibility to infection induced morbidity/mortality ( J:191055 )

• reduction in disease free survival

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:191055 )

• reduction in disease free survival

hematopoietic system

increased neutrophil cell number ( J:191055 )

integument

skin inflammation ( J:191055 )

• neutrophil infiltration of the dermis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24