All Phenotypes Mobq6<CAST/EiJ> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mobq6^CAST/EiJ
CAST/EiJ
MGI:2155134

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mobq6^CAST/EiJ/Mobq6^CAST/EiJ	B6.CAST-Mobq6^CAST/EiJ	MGI:3711213
ht2	Mobq6^CAST/EiJ/Mobq6^C57BL/6J	involves: CAST/Ei * C57BL/6J	MGI:2175356
cx3	Ldlr^tm1Her/Ldlr^tm1Her Mobq6^CAST/EiJ/Mobq6^CAST/EiJ	B6.CAST-Mobq6^CAST/EiJ	MGI:3711214

Allelic Composition	Mobq6^CAST/EiJ/Mobq6^CAST/EiJ
Genetic Background	B6.CAST-Mobq6^CAST/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:116503 )

• decreased obesity on a Western diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:116503 )

• decreased obesity on a Western diet

Allelic Composition	Mobq6^CAST/EiJ/Mobq6^C57BL/6J
Genetic Background	involves: CAST/Ei * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased white adipose tissue amount ( J:48038 )

homeostasis/metabolism

decreased triglyceride lipase activity ( J:48038 )

• decreased hepatic lipase activity

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Mobq6^CAST/EiJ/Mobq6^CAST/EiJ
Genetic Background	B6.CAST-Mobq6^CAST/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (81 available)
Mobq6^CAST/EiJ mutation (0 available); any Mobq6 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:116503 )

• decreased obesity on a Western diet

decreased circulating cholesterol level ( J:116503 )

• decreased plasma cholesterol

• decreased unesterified cholesterol

decreased circulating HDL cholesterol level ( J:116503 )

decreased circulating LDL cholesterol level ( J:116503 )

decreased circulating VLDL cholesterol level ( J:116503 )

improved glucose tolerance ( J:116503 )

• improved glucose tolerance on a Western diet

cardiovascular system

decreased susceptibility to atherosclerosis ( J:116503 )

• reduced aortic root lesion size (2-3 fold smaller)

behavior/neurological

abnormal food intake ( J:116503 )

• increased food efficiency

growth/size/body

decreased susceptibility to diet-induced obesity ( J:116503 )

• decreased obesity on a Western diet

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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