Phenotypes associated with this allele

• Allele Symbol: Myo7a^816SB
• Allele Name: shaker 816SB
• Allele ID: MGI:2155423
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo7a^816SB/Myo7a^816SB	involves: BALB/cRl	MGI:3587760
hm2	Myo7a^816SB/Myo7a^816SB	involves: BALB/cRl * 47BS/Rl	MGI:3587763

Genotype
MGI:3587760

hm1

• Allelic Composition: Myo7a^816SB/Myo7a^816SB
• Genetic Background: involves: BALB/cRl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal hair cell morphology ( J:49926 )

• abnormal hair cell development

abnormal hearing physiology ( J:49926 )

• no cochlear electrophysiology responses

nervous system

abnormal hair cell morphology ( J:49926 )

• abnormal hair cell development

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Usher syndrome type 1		DOID:0110826	OMIM:276900	J:42644

Genotype
MGI:3587763

hm2

• Allelic Composition: Myo7a^816SB/Myo7a^816SB
• Genetic Background: involves: BALB/cRl * 47BS/Rl

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:46373 )

• disorganized formation of stereocilia rows

• some hair cells with several small clumps of stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles ( J:46373 )

• orientation of rows of cochlear hair cell stereocilia erratic

absent cochlear microphonics ( J:46373 )

• no cochlear microphonics responses

abnormal auditory summating potential ( J:46373 )

• no summating potential responses

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:46373 )

• disorganized formation of stereocilia rows

• some hair cells with several small clumps of stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles ( J:46373 )

• orientation of rows of cochlear hair cell stereocilia erratic

absent cochlear microphonics ( J:46373 )

• no cochlear microphonics responses

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Usher syndrome type 1		DOID:0110826	OMIM:276900	J:46373