Phenotypes associated with this allele

• Allele Symbol: Dlx3^tm1Mso
• Allele Name: targeted mutation 1, Maria I Morasso
• Allele ID: MGI:2155443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlx3^tm1Mso/Dlx3^tm1Mso	involves: 129S1/Sv * 129X1/SvJ * CF-1	MGI:2176446

Genotype
MGI:2176446

hm1

• Allelic Composition: Dlx3^tm1Mso/Dlx3^tm1Mso
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CF-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:52247 )

• at E9.5, homozygous mutant embryos were represented at approximately Mendelian ratios

• mutant embryos died between E9.5 and E10; no mutant embryos were detected later than E12.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:52247 )

• vascularization appeared to be less extensive in the mutant labyrinthine layer, resulting in a compact morphology

abnormal pericardium morphology ( J:52247 )

• at E9.5, the mutant pericardium appeared swollen, indicating a disturbance of fluid balance across the yolk sac and an accumulation of blood in the embryo

embryo

embryonic growth arrest ( J:52247 )

• homozygous mutant embryos exhibited developmental arrest shortly after E9.5

• by E12.5, mostly empty residual decidual swellings were found

abnormal spongiotrophoblast layer morphology ( J:52247 )

• by E12.5, the spongiotrophoblast and labyrinthine layers were significantly reduced in size and appeared very compact in the mutant placenta

abnormal placenta labyrinth morphology ( J:52247 )

• in the mutant labyrinthine layer, only very few fetal red blood cells (RBCs) were observed: most of these fetal RBCs were found in the periphery, and those located more internally within the labyrinthine layer exhibited fragmented nuclear morphology

abnormal placental labyrinth vasculature morphology ( J:52247 )

• vascularization appeared to be less extensive in the mutant labyrinthine layer, resulting in a compact morphology

absent placental labyrinth ( J:52247 )

• in homozygous mutant embryos, the characteristic labyrinths were absent

abnormal placenta development ( J:52247 )

• by E12.5, the spongiotrophoblast and labyrinthine layers were significantly reduced in size and appeared very compact in the mutant placenta

• also, the parietal and visceral yolk sacs were not as tightly associated with the mutant placenta

• by E12.5, homozygous mutant embryos showed significant defects in the placental vascular system