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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd3etm1Cpt
targeted mutation 1, Cox Terhorst
MGI:2155671
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd3etm1Cpt/Cd3etm1Cpt involves: 129S4/SvJae * C57BL/6 MGI:3850635
cx2
 		Cd3etm1Cpt/Cd3etm1Cpt
Tg(CD3E)26Cpt/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:3850637


Genotype
MGI:3850635
hm1
Allelic
Composition		 Cd3etm1Cpt/Cd3etm1Cpt
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1Cpt mutation (0 available); any Cd3e mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:54756 )
• thymic cellularity is 3% of normal
decreased double-positive T cell number ( J:54756 )
• double-positive thymocytes are absent in these mice
absent T cells ( J:54756 )
• alpha-beta and gamma-delta T cells are absent in these mice

hematopoietic system
thymus hypoplasia ( J:54756 )
• thymic cellularity is 3% of normal
decreased double-positive T cell number ( J:54756 )
• double-positive thymocytes are absent in these mice
absent T cells ( J:54756 )
• alpha-beta and gamma-delta T cells are absent in these mice

endocrine/exocrine glands
thymus hypoplasia ( J:54756 )
• thymic cellularity is 3% of normal




Genotype
MGI:3850637
cx2
Allelic
Composition		 Cd3etm1Cpt/Cd3etm1Cpt
Tg(CD3E)26Cpt/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1Cpt mutation (0 available); any Cd3e mutation (54 available)
Tg(CD3E)26Cpt mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:54756 )
• thymic cellularity is half of normal
decreased T cell number ( J:54756 )
• T cell numbers are reduced by about 60%
decreased double-positive T cell number ( J:54756 )
• double-positive thymocyte numbers are only about 17% of total thymocytes compared to 85% in wild-type controls

hematopoietic system
thymus hypoplasia ( J:54756 )
• thymic cellularity is half of normal
decreased T cell number ( J:54756 )
• T cell numbers are reduced by about 60%
decreased double-positive T cell number ( J:54756 )
• double-positive thymocyte numbers are only about 17% of total thymocytes compared to 85% in wild-type controls

endocrine/exocrine glands
thymus hypoplasia ( J:54756 )
• thymic cellularity is half of normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory