Phenotypes associated with this allele

• Allele Symbol: Gjb2^tm1Kwi
• Allele Name: targeted mutation 1, Klaus Willecke
• Allele ID: MGI:2155739
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjb2^tm1Kwi/Gjb2^tm1Kwi	involves: 129P2/OlaHsd * C57BL/6	MGI:3588778

Genotype
MGI:3588778

hm1

• Allelic Composition: Gjb2^tm1Kwi/Gjb2^tm1Kwi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size of Gjb2^tm1Kwi/Gjb2^tm1Kwi embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:46665 )

• die around E11

embryo

abnormal placental labyrinth vasculature morphology ( J:46665 )

• fewer embryonic blood vessels

decreased embryo size ( J:46665 )

• significantly smaller at E10.5 than wild-type

decreased placental labyrinth size ( J:46665 )

• appears smaller than in wild-type

abnormal placenta development ( J:46665 )

• retarded placental development at E10.5

abnormal placental transport ( J:46665 )

• 60% decrease in transplacental uptake of 3-O-[¹⁴C]methylglucose compared to wild-type

growth/size/body

decreased embryo size ( J:46665 )

• significantly smaller at E10.5 than wild-type

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:46665 )

• fewer embryonic blood vessels