All Phenotypes Dnmt3l<tm1Bes> MGI Mouse

mortality/aging

prenatal lethality, complete penetrance ( J:73452 )

• no viable pups are recovered at birth from homozygous females

embryo

abnormal ectoplacental cone morphology ( J:73452 )

• excess maternal blood is found near the ectoplacental cone in embryos from homozygous females

abnormal trophoblast layer morphology ( J:73452 )

• the secondary trophoblastic giant cells hyperproliferate resulting in overgrowth of the chorion that is seen in embryos from homozygous females

increased trophoblast giant cell number ( J:73452 )

• the secondary trophoblastic giant cells hyperproliferate

abnormal visceral yolk sac endoderm morphology ( J:73452 )

• hyperproliferation of the yolk sac endoderm is seen in embryos from homozygous females

failure of chorioallantoic fusion ( J:73452 )

• the chorioallantoic fusion fails in embryos from homozygous females

nervous system

exencephaly ( J:73452 )

• exencephaly and other neural tube defects are seen in embryos from homozygous females

reproductive system

decreased male germ cell number ( J:128710 )

• by P10, males have about a quarter of the number of germ cells as heterozygous littermates

abnormal oogenesis ( J:73452 )

• failure of maternal methylated gene imprinting is seen in homozygous females

small testis ( J:73452 )

• adult males have severe hypogonadism

abnormal spermatogenesis ( J:128710 )

• delayed entry of germ cells into meiosis, as indicated by a lower frequency of tubules containing gamma-H2AX positive cells in 10-day old males

• male germ cells exhibit abnormal methylation of paternally imprinted genes

azoospermia ( J:73452 )

• seminiferous tubules contain only Sertoli cells

infertility ( J:73452 )

• both sexes are sterile

female infertility ( J:73452 )

male infertility ( J:73452 )

cardiovascular system

pericardial edema ( J:73452 )

• pericardial edema is seen in embryos from homozygous females

endocrine/exocrine glands