Phenotypes associated with this allele

• Allele Symbol: Alcw2^C57BL/6J
• Allele Name: C57BL/6J
• Allele ID: MGI:2155929
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alcw2^C57BL/6J/Alcw2^C57BL/6J	D2.B6-Alcw2^C57BL/6J	MGI:3832230
hm2	Alcw2^C57BL/6J/Alcw2^C57BL/6J	involves: C57BL/6J * DBA/2J	MGI:2673029

Genotype
MGI:3832230

hm1

• Allelic Composition: Alcw2^C57BL/6J/Alcw2^C57BL/6J
• Genetic Background: D2.B6-Alcw2^C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to alcohol ( J:143371 )

• decreased alcohol withdrawal severity

decreased behavioral withdrawal response ( J:143371 )

• decreased alcohol withdrawal severity

nervous system

abnormal nervous system electrophysiology ( J:143371 )

• decreased neuronal activation during alcohol withdrawal in the ventral pallidum (VP), rostromedial lateral globus pallidum (LGP), medial globus pallidus (MGP), subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr)

Genotype
MGI:2673029

hm2

• Allelic Composition: Alcw2^C57BL/6J/Alcw2^C57BL/6J
• Genetic Background: involves: C57BL/6J * DBA/2J

behavior/neurological

decreased behavioral withdrawal response ( J:76251 , J:88800 )

• decreased alcohol withdrawal risk (J:76251)

• decreased alcohol and pentobarbital withdrawal severity (J:88800)