Phenotypes associated with this allele

• Allele Symbol: Ace^tm3Unc
• Allele Name: targeted mutation 3, University of North Carolina
• Allele ID: MGI:2155951
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm3Unc/Ace^tm3Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3799525
ht2	Ace^tm3Unc/Ace^+	B6.129P2-Ace^tm3Unc	MGI:3799530
ht3	Ace^tm3Unc/Ace^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3799524

Genotype
MGI:3799525

hm1

• Allelic Composition: Ace^tm3Unc/Ace^tm3Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart weight ( J:42519 )

• mice exhibit a lower heart weight than in wild-type mice but is not different from heart weights in heterozygous mice

decreased heart rate ( J:42519 )

• mice exhibit a lower heart rate than in wild-type and heterozygous mice

renal/urinary system

abnormal kidney cortex morphology ( J:42519 )

• cortical width is decreased compared to wild-type and heterogyzous mice

abnormal renal glomerulus morphology ( J:42519 )

• mice exhibit decreased tubulointerstitial tissue per glomerulus compared to wild-type and heterogyzous mice

Genotype
MGI:3799530

ht2

• Allelic Composition: Ace^tm3Unc/Ace⁺
• Genetic Background: B6.129P2-Ace^tm3Unc

homeostasis/metabolism

albuminuria ( J:72577 )

• in streptozotocin-induced diabetic, urinary albumin is nearly doubled compared to similarly treated wild-type mice and continues to increase with age

• however, mice fail to exhibit evidence of structural renal injury

cardiovascular system

increased systemic arterial blood pressure ( J:72577 )

• in streptozotocin-induced diabetic mice

renal/urinary system

albuminuria ( J:72577 )

• in streptozotocin-induced diabetic, urinary albumin is nearly doubled compared to similarly treated wild-type mice and continues to increase with age

• however, mice fail to exhibit evidence of structural renal injury

Genotype
MGI:3799524

ht3

• Allelic Composition: Ace^tm3Unc/Ace⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

growth/size/body

decreased body weight ( J:128859 )

• based on weight normalized by food consumption, mice are thinner than wild-type mice

• when fed a high fat diet for 27 weeks, mice weigh less than wild-type mice and Ace^tm1Unc heterozygotes

• decreased weight when fed a high fat diet cannot be reversed with treatment with losartan (an angiotensin AT1 antagonist)

renal/urinary system

abnormal kidney cortex morphology ( J:42519 )

• cortical width is decreased compared to wild-type

abnormal renal glomerulus morphology ( J:42519 )

• mice exhibit decreased tubulointerstitial tissue per glomerulus compared to in wild-type mice

cardiovascular system

decreased heart weight ( J:42519 )

decreased heart rate ( J:42519 )

adipose tissue

abnormal epididymal fat pad morphology ( J:128859 )

• when fed a high fat diet, peri-epididymal adipose tissue is reduced

behavior/neurological

increased food intake ( J:128859 )

• food consumption is increased on a normal diet in order to maintain a normal body weight

endocrine/exocrine glands

decreased insulin secretion ( J:128859 )

• compared to in Ace^tm1Unc heterozygotes when fed a high fat diet

homeostasis/metabolism

decreased insulin secretion ( J:128859 )

• compared to in Ace^tm1Unc heterozygotes when fed a high fat diet