Phenotypes associated with this allele

• Allele Symbol: Ada^tm1Vlr
• Allele Name: targeted mutation 1, Dinko Valerio
• Allele ID: MGI:2155977
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ada^tm1Vlr/Ada^tm1Vlr	either: 129P2/OlaHsd-Ada^tm1Vlr or (involves: (129P2/OlaHsd * FVB/N)	MGI:2183044

Genotype
MGI:2183044

hm1

• Allelic Composition: Ada^tm1Vlr/Ada^tm1Vlr
• Genetic Background: either: 129P2/OlaHsd-Ada^tm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:26731 )

• most dead within 2 hours of birth, although a few survived to 2 days

hematopoietic system

extramedullary hematopoiesis ( J:26731 )

• more extensive than in control animals

homeostasis/metabolism

cyanosis ( J:26731 )

• evident preceeding death

liver/biliary system

hepatic necrosis ( J:26731 )

intrahepatic cholestasis ( J:26731 )

respiratory system

abnormal pulmonary alveolus morphology ( J:26731 )

• small alveolar spaces

atelectasis ( J:26731 )

digestive/alimentary system

abnormal small intestine morphology ( J:26731 )

• necrosis of the small intestine