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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plcg1tm1Ine
targeted mutation 1, Izumi Negishi
MGI:2155982
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plcg1tm1Ine/Plcg1tm1Ine involves: 129P2/OlaHsd MGI:3629731


Genotype
MGI:3629731
hm1
Allelic
Composition		 Plcg1tm1Ine/Plcg1tm1Ine
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg1tm1Ine mutation (0 available); any Plcg1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal embryonic hematopoiesis ( J:73254 )
• macroscopically, E9.5 homozygotes exhibit extremely reduced hematopoiesis relative to wild-type embryos
• in vitro, mutant ES cells exhibit significantly reduced differentiation into hematopoietic cells relative to wild-type ES cells

hematopoietic system
abnormal embryonic hematopoiesis ( J:73254 )
• macroscopically, E9.5 homozygotes exhibit extremely reduced hematopoiesis relative to wild-type embryos
• in vitro, mutant ES cells exhibit significantly reduced differentiation into hematopoietic cells relative to wild-type ES cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory