Phenotypes associated with this allele

• Allele Symbol: Clgn^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:2156041
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clgn^tm1Osb/Clgn^tm1Osb	either: 129 or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:2451152

Genotype
MGI:2451152

hm1

• Allelic Composition: Clgn^tm1Osb/Clgn^tm1Osb
• Genetic Background: either: 129 or (involves: 129P2/OlaHsd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:40831 )

♂N • males exhibit normal testes size and weight with no defects in spermatogenesis, sperm morphology or motility

♂N • copulation and vaginal plug formation are normal

male infertility ( J:40831 )

♂ • males are nearly sterile

impaired fertilization ( J:79546 )

• impaired sperm-zona pellucida binding/and or sperm transit to the oviduct

• initial description of impaired EPM binding amended: mutant sperm capable of binding and fusing to the egg plasma membrane (EPM)

impaired binding of sperm to zona pellucida ( J:40831 )

♂ • in vitro, sperm cannot bind to the zona pellucida; removal of cumulus cells revealed that sperm fail to adhere to the egg despite frequent collisions with the zona pellucida