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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aicdatm1Hon
targeted mutation 1, Tasuku Honjo
MGI:2156156
Summary 17 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aicdatm1Hon/Aicdatm1Hon involves: C57BL/6 * CBA MGI:2654846
ht2
 		Aicdatm1Hon/Aicda+ involves: C57BL/6 * CBA MGI:3809683
ht3
 		Aicdatm1Hon/Aicdatm1.1Fwa involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj MGI:5566788
ht4
 		Aicdatm1Hon/Aicdatm4Mnz involves: C57BL/6 * CBA MGI:3818481
ht5
 		Aicdatm1Hon/Aicdatm2Mnz involves: C57BL/6 * CBA MGI:3809682
ht6
 		Aicdatm1Hon/Aicdatm3Mnz involves: C57BL/6 * CBA MGI:3818480
cn7
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * CBA MGI:4452376
cn8
 		Aicdatm1Hon/Aicdatm1Hon
Tg(Cr2-cre)3Cgn/?
Xrcc4tm1Fwa/Xrcc4tm2Fwa 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA MGI:4352686
cx9
 		Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484523
cx10
 		Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * CBA/JNCrlj * SJL MGI:5484525
cx11
 		Aicdatm1Hon/Aicdatm1Hon
Ighmtm1.1(IGH-2)Cog/Ighm+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:4437207
cx12
 		Aicdatm1Hon/Aicdatm1Hon
Bcl6tm1.1Jwan/Bcl6tm1.1Jwan 		involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj MGI:5449735
cx13
 		Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484527
cx14
 		Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+ 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484524
cx15
 		Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5441335
cx16
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: C57BL/6 * CBA MGI:3836398
cx17
 		Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+ 		involves: C57BL/6 * CBA/JNCrlj * SJL MGI:5484526


Genotype
MGI:2654846
hm1
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:169227 )
• following administration of 15 ug cholera toxin

immune system
abnormal class switch recombination ( J:73659 , J:120658 , J:141427 )
• absent class switching in B cells (J:73659)
• class switching recombination (CSR)-induced Smu internal deletion is impaired (J:120658)
• B cells cultured with LPS and IL-4 fail to switch immunoglobulin expression to IgG1 (J:141427)
• similar defects in IgG3 switching are also observed (J:141427)
abnormal somatic hypermutation frequency ( J:136224 , J:141427 )
• mice exhibit an increase in somatic hypermutation rates compared to in wild-type mice (J:136224)
• the somatic mutation rates of the upstream region of the S-mu switch is severely reduced (J:141427)
increased germinal center B cell number ( J:169227 )
• in Peyer's patches and spleen
• in the lamina propria and Peyer's patches
decreased IgA level ( J:169227 )
• serum and fecal
decreased IgG1 level ( J:73659 , J:169227 )
• levels are less than one tenth of those in controls (J:73659)
decreased IgG2a level ( J:73659 )
• levels are less than one tenth of those in controls
increased IgM level ( J:73659 , J:169227 )
• 2-3 fold elevation in IgM level (J:73659)
• fecal (J:169227)
increased susceptibility to bacterial infection induced morbidity/mortality ( J:169227 )
• following administration of 15 ug cholera toxin

hematopoietic system
abnormal class switch recombination ( J:73659 , J:120658 , J:141427 )
• absent class switching in B cells (J:73659)
• class switching recombination (CSR)-induced Smu internal deletion is impaired (J:120658)
• B cells cultured with LPS and IL-4 fail to switch immunoglobulin expression to IgG1 (J:141427)
• similar defects in IgG3 switching are also observed (J:141427)
abnormal somatic hypermutation frequency ( J:136224 , J:141427 )
• mice exhibit an increase in somatic hypermutation rates compared to in wild-type mice (J:136224)
• the somatic mutation rates of the upstream region of the S-mu switch is severely reduced (J:141427)
increased germinal center B cell number ( J:169227 )
• in Peyer's patches and spleen
• in the lamina propria and Peyer's patches
decreased IgA level ( J:169227 )
• serum and fecal
decreased IgG1 level ( J:73659 , J:169227 )
• levels are less than one tenth of those in controls (J:73659)
decreased IgG2a level ( J:73659 )
• levels are less than one tenth of those in controls
increased IgM level ( J:73659 , J:169227 )
• 2-3 fold elevation in IgM level (J:73659)
• fecal (J:169227)




Genotype
MGI:3809683
ht2
Allelic
Composition		 Aicdatm1Hon/Aicda+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:136224 )
N
• mice exhibit normal somatic hypermutation rates
abnormal class switch recombination ( J:136224 , J:141427 )
• class switching is impaired compared to in wild-type mice (J:136224)
• B cells show 80% the level of class switch recombination (CSR) to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4 (J:141427)
abnormal somatic hypermutation frequency ( J:141427 )
• somatic hypermutation by germinal center B cells is 75% of what occurs in wild-type
• somatic hypermutation by Peyer's patch B cells is 40% of what occurs in wild-type

hematopoietic system
abnormal class switch recombination ( J:136224 , J:141427 )
• class switching is impaired compared to in wild-type mice (J:136224)
• B cells show 80% the level of class switch recombination (CSR) to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4 (J:141427)
abnormal somatic hypermutation frequency ( J:141427 )
• somatic hypermutation by germinal center B cells is 75% of what occurs in wild-type
• somatic hypermutation by Peyer's patch B cells is 40% of what occurs in wild-type




Genotype
MGI:5566788
ht3
Allelic
Composition		 Aicdatm1Hon/Aicdatm1.1Fwa
Genetic
Background		 involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1.1Fwa mutation (0 available); any Aicda mutation (57 available)
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:209271 )
N
• mice exhibit normal numbers of splenic B and T cells and response to activation
abnormal class switch recombination ( J:209271 )
• severely decreased class switch recombination to IgG1 and IgG3

hematopoietic system
abnormal class switch recombination ( J:209271 )
• severely decreased class switch recombination to IgG1 and IgG3




Genotype
MGI:3818481
ht4
Allelic
Composition		 Aicdatm1Hon/Aicdatm4Mnz
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Aicdatm4Mnz mutation (0 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:141427 )
• B cells show 45% the level of class switch recombination to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
abnormal somatic hypermutation frequency ( J:141427 )
• the somatic mutation rate of the upstream region of the S-mu switch repeats is 85% the rate that occurs in stimulated wild-type B cells
• somatic hypermutation by germinal center and Peyer's patch B cells does not exceed basal mutation rates

hematopoietic system
abnormal class switch recombination ( J:141427 )
• B cells show 45% the level of class switch recombination to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
abnormal somatic hypermutation frequency ( J:141427 )
• the somatic mutation rate of the upstream region of the S-mu switch repeats is 85% the rate that occurs in stimulated wild-type B cells
• somatic hypermutation by germinal center and Peyer's patch B cells does not exceed basal mutation rates




Genotype
MGI:3809682
ht5
Allelic
Composition		 Aicdatm1Hon/Aicdatm2Mnz
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Aicdatm2Mnz mutation (1 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:136224 )
• B cells exhibit a 3- to 6-fold increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicdatm1Hon heterozygotes

immune system
immune system phenotype ( J:136224 )
N
• mice exhibit normal B cell development in the bone marrow, peripheral B cell numbers in the spleen, serum immunoglobulin isotypes, class switching, and somatic hypermutation rates




Genotype
MGI:3818480
ht6
Allelic
Composition		 Aicdatm1Hon/Aicdatm3Mnz
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Aicdatm3Mnz mutation (0 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:141427 )
• B cells show 4% the level of class switch recombination (CSR) to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
abnormal somatic hypermutation frequency ( J:141427 )
• the somatic mutation rate of the upstream region of the S-mu switch repeats is 25% the rate that occurs in stimulated wild-type B cells
• somatic hypermutation by germinal center and Peyer's patch B cells does not exceed basal mutation rates

hematopoietic system
abnormal class switch recombination ( J:141427 )
• B cells show 4% the level of class switch recombination (CSR) to IgG1 that occurs with wild-type controls when cultured in the presence of LPS and IL-4
abnormal somatic hypermutation frequency ( J:141427 )
• the somatic mutation rate of the upstream region of the S-mu switch repeats is 25% the rate that occurs in stimulated wild-type B cells
• somatic hypermutation by germinal center and Peyer's patch B cells does not exceed basal mutation rates




Genotype
MGI:4452376
cn7
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:159173 )
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells

immune system
abnormal class switch recombination ( J:159173 )
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells




Genotype
MGI:4352686
cn8
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Tg(Cr2-cre)3Cgn/?
Xrcc4tm1Fwa/Xrcc4tm2Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
Xrcc4tm1Fwa mutation (0 available); any Xrcc4 mutation (26 available)
Xrcc4tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:150339 )
• genomic stability is disrupted in activated B cells with chromosome breakage occurring in close to half of cells
• however, there is no increased breakage of the Igh locus compared to wild-type controls
• there is increased breakage at the Igk and Igl loci with 1% of stimulated B cells demonstrating this




Genotype
MGI:5484523
cx9
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
• treatment with a small molecular inhibitor of Mre11a or Wrn produces no effect on resection of microhomology at the junctions

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
• treatment with a small molecular inhibitor of Mre11a or Wrn produces no effect on resection of microhomology at the junctions




Genotype
MGI:5484525
cx10
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * CBA/JNCrlj * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Exo1tm1Wed mutation (0 available); any Exo1 mutation (46 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells




Genotype
MGI:4437207
cx11
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ighmtm1.1(IGH-2)Cog mutation (0 available); any Ighm mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:157575 )
• mIgA1+ cells compete poorly for entry into mucosa-associated lymphoid tissues compared with wild-type cells

hematopoietic system
abnormal B cell physiology ( J:157575 )
• mIgA1+ cells compete poorly for entry into mucosa-associated lymphoid tissues compared with wild-type cells




Genotype
MGI:5449735
cx12
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Bcl6tm1.1Jwan/Bcl6tm1.1Jwan
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Bcl6tm1.1Jwan mutation (0 available); any Bcl6 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal somatic hypermutation frequency ( J:190534 )
• mice fail to exhibit mutations in the knock-in allele

immune system
abnormal somatic hypermutation frequency ( J:190534 )
• mice fail to exhibit mutations in the knock-in allele




Genotype
MGI:5484527
cx13
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Blmtm3Brd mutation (1 available); any Blm mutation (88 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194603 )
N
• B cells exhibit normal resection and junctional microhomology




Genotype
MGI:5484524
cx14
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells




Genotype
MGI:5441335
cx15
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Tg(Igkv3-5*-MYC)#Plbe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Tg(Igkv3-5*-MYC)#Plbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131912 )
N
• unlike Tg(Igkv3-5*-Myc)#Plbe mice, no spikes in monoclonal antibodies (M-spikes) are observed
• mice exhibit fewer plasma cells in the bone marrow compared with Tg(Igkv3-5*-Myc)#Plbe mice




Genotype
MGI:3836398
cx16
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:145691 )
• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15
• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles
• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions
• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes




Genotype
MGI:5484526
cx17
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Genetic
Background		 involves: C57BL/6 * CBA/JNCrlj * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Exo1tm1Wed mutation (0 available); any Exo1 mutation (46 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory