All Phenotypes Bcl2<tm1Dlo> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo
Genetic Background	B6.129P2-Bcl2^tm1Dlo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The Bcl2l11^tm3.1Boui mutation ameliorates the degenerative disorders of Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

mortality/aging

premature death ( J:73316 , J:104487 , J:153846 )

• Background Sensitivity: this phenotype is more severe on an inbred C57BL/6 background than on a mixed 129 C57BL/6 background (J:73316)

• all homozygotes die from polycystic kidney disease between 3 and 8 weeks of age (J:73316)

• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age (J:104487)

• die by 50 days of age from the renal failure induced by polycystic kidney disease (PKD) (J:153846)

growth/size/body

short ears ( J:73316 )

• all homozygotes have short ears

kidney cyst ( J:73316 , J:104487 )

• Background Sensitivity: this phenotype is more severe on an inbred C57BL/6 background than on a mixed 129 C57BL/6 background (J:73316)

• some cysts are present at P0 (J:73316)

polycystic kidney ( J:73316 , J:153846 )

• all homozygotes die from polycystic kidney disease between 3 and 8 weeks of age (J:73316)

• die by 50 days of age from the renal failure induced by polycystic kidney disease (PKD) (J:153846)

decreased body size ( J:73316 , J:104487 , J:153846 )

• Background Sensitivity: this phenotype is more severe on an inbred C57BL/6 background than on a mixed 129 C57BL/6 background (J:73316)

• all homozygotes become runted (J:73316)

• become runted (J:153846)

decreased body weight ( J:153846 )

• decreased body weight at day 40

hearing/vestibular/ear

short ears ( J:73316 )

• all homozygotes have short ears

immune system

increased splenocyte apoptosis ( J:153846 )

• presence of many apoptotic cell clusters

abnormal leukopoiesis ( J:73316 )

• irradiated mice reconstituted with mutant fetal liver cells have a 4- to 5- fold reduction in lymphocytes and myeloid cells compared to controls

decreased spleen weight ( J:153846 )

• 5-10 mg vs. 60-100 mg in wild type

spleen atrophy ( J:153846 )

• atrophied spleen

decreased spleen white pulp amount ( J:153846 )

• very few lymphoid follicles

abnormal lymphocyte physiology ( J:73316 , J:104487 )

• survival of mature resting T and B cells in the absence of cytokines is impaired compared to wild-type cells (J:73316)

increased B cell apoptosis ( J:73316 )

• less than 1% of B cells are alive after 4 days of culturing without cytokines compared to over 10% of controls

increased T cell apoptosis ( J:73316 )

• less than 1% of T cells are alive after 4 days of culturing without cytokines compared to over 10% of controls

• culturing with IL-7 fails to rescue T cells from apoptosis

renal/urinary system

kidney cyst ( J:73316 , J:104487 )

• Background Sensitivity: this phenotype is more severe on an inbred C57BL/6 background than on a mixed 129 C57BL/6 background (J:73316)

• some cysts are present at P0 (J:73316)

polycystic kidney ( J:73316 , J:153846 )

• all homozygotes die from polycystic kidney disease between 3 and 8 weeks of age (J:73316)

• die by 50 days of age from the renal failure induced by polycystic kidney disease (PKD) (J:153846)

abnormal kidney development ( J:73316 )

• at E15.5 metanephroi are smaller mostly as a result of reduced mesenchymal area of the cortex

• neonates have fewer nephrons and a narrower nephrogenic area

abnormal kidney mesenchyme morphology ( J:153846 )

• at E15.5 the mesenchymal area of the cortex is reduced

small metanephros ( J:73316 )

• at E15.5 metanephroi are smaller mostly as a result of reduced mesenchymal area of the cortex

abnormal nephrogenic zone morphology ( J:73316 )

• neonates exhibit a narrower nephrogenic area

decreased nephron number ( J:73316 )

• neonates have fewer nephrons

craniofacial

short ears ( J:73316 )

• all homozygotes have short ears

hematopoietic system

increased splenocyte apoptosis ( J:153846 )

• presence of many apoptotic cell clusters

abnormal leukopoiesis ( J:73316 )

• irradiated mice reconstituted with mutant fetal liver cells have a 4- to 5- fold reduction in lymphocytes and myeloid cells compared to controls

decreased spleen weight ( J:153846 )

• 5-10 mg vs. 60-100 mg in wild type

spleen atrophy ( J:153846 )

• atrophied spleen

decreased spleen white pulp amount ( J:153846 )

• very few lymphoid follicles

abnormal lymphocyte physiology ( J:73316 , J:104487 )

• survival of mature resting T and B cells in the absence of cytokines is impaired compared to wild-type cells (J:73316)

increased B cell apoptosis ( J:73316 )

• less than 1% of B cells are alive after 4 days of culturing without cytokines compared to over 10% of controls

increased T cell apoptosis ( J:73316 )

• less than 1% of T cells are alive after 4 days of culturing without cytokines compared to over 10% of controls

• culturing with IL-7 fails to rescue T cells from apoptosis

cellular

increased B cell apoptosis ( J:73316 )

• less than 1% of B cells are alive after 4 days of culturing without cytokines compared to over 10% of controls

increased T cell apoptosis ( J:73316 )

• less than 1% of T cells are alive after 4 days of culturing without cytokines compared to over 10% of controls

• culturing with IL-7 fails to rescue T cells from apoptosis

increased splenocyte apoptosis ( J:153846 )

• presence of many apoptotic cell clusters

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

\AlleleSymbol (MGI:2156165|0)/Bcl2^tm1Dlo with littermate control

mortality/aging

postnatal lethality, incomplete penetrance ( J:73660 )

• about 50% die between 1 and 6 weeks after birth

pigmentation

abnormal coat/hair pigmentation ( J:73660 )

• hair color turns gray postnatally between 4 and 5 weeks, however skin is normal

growth/size/body

round snout ( J:73660 )

• rounder nose

small ears ( J:73660 )

polycystic kidney ( J:73660 )

• kidneys exhibit a polycystic appearance

decreased body size ( J:73660 )

decreased body weight ( J:73660 )

• body weight is 30-90% of controls

immune system

abnormal T cell differentiation ( J:73660 )

decreased lymphocyte cell number ( J:73660 )

• number of lymphocytes in the peripheral blood, bone marrow, thymus, spleen, and lymph nodes decreases with age, while the number of segmented neutrophils and other hematopoietic lineages is normal

decreased thymocyte number ( J:73660 )

decreased mature B cell number ( J:73660 )

• more than 80% reduction of B220⁺/surface immunoglobulin-positive mature B cells in the bone marrow

decreased pre-B cell number ( J:73660 )

• more than 80% reduction of B220⁺ surface immunoglobulin-negative pre-B cells in the bone marrow

decreased CD8-positive, alpha-beta T cell number ( J:73660 )

• accelerated decrease over time in the percentage of CD4-CD8+ cells in the periphery

renal/urinary system

increased kidney apoptosis ( J:33776 , J:111022 )

• at E13-E16, homozygotes show a 5-fold increase in nick end-labeled apoptotic cells per kidney area relative to wild-type controls (J:33776)

• at E13-E16, apoptotic cells and phagocytosed apoptotic bodies are often detected among uninduced mesenchymal cells and less frequently among induced tubular and peritubular cells (J:33776)

• at E13-E16, projections from intact mesenchymal cells are in contact with the cell membrane of apoptotic cells; in some cases, 2-3 apoptotic cells are seen together (J:33776)

• at E17-E19, homozygotes show a 5-fold increase in apoptotic cells per nephrogenic zone relative to wild-type and heterozygous controls (J:33776)

• increased kidney apoptosis throughout the tubular epithelium and the interstitium after P20 (J:111022)

• apoptosis is neither found in non-sclerotic glomeruli nor in stages prior to sclerosis (P20) (J:111022)

increased renal glomerulus apoptosis ( J:111022 )

• apoptotic bodies first seen in severely injured or sclerotic glomeruli at P20

abnormal kidney morphology ( J:73660 )

• kidneys have a nonsmooth surface, are pale, and exhibit interstitial hyperproliferation

abnormal kidney vasculature morphology ( J:111022 )

• at P13, renal arteries and veins are abnormally located immediately beneath the kidney surface

polycystic kidney ( J:73660 )

• kidneys exhibit a polycystic appearance

abnormal kidney cortex morphology ( J:73660 , J:111022 )

	• disarray of the cortex structure (J:73660)
	• at P7-8, the renal cortex is thin, abnormally formed, and composed of only one nephron layer, unlike in control mice (J:111022)

abnormal glomerular capsule parietal layer morphology ( J:111022 )

• vacuolar degeneration of parietal epithelial cells after P20

decreased glomerular capsule space ( J:111022 )

• loss of urinary space at sites of glomerular synechiae

abnormal podocyte morphology ( J:111022 )

• starting at P12, podocytes show striking injuries, including cell body attenuation, pseudocyst formation, and accumulation of lysosomal elements

• vacuolar degeneration of podocytes after P20

podocyte foot process effacement ( J:111022 )

• foot process effacement starting at P12

podocyte hypertrophy ( J:111022 )

• binucleated podocytes are occasionally observed, indicating extreme cell hypertrophy

abnormal renal glomerulus morphology ( J:33776 )

• at E17-E19, no centrifugal maturation of glomeruli is observed, unlike in control mice

abnormal glomerular capillary endothelium morphology ( J:111022 )

• nuclear shrinkage of endothelial cells after P20

expanded mesangial matrix ( J:111022 )

• increased matrix deposition starting at P12

mesangiolysis ( J:111022 )

• focal mesangiolysis starting at P12

glomerulosclerosis ( J:111022 )

• starting at P20, enlarged glomeruli develop segmental sclerosis rapidly progressing to global sclerosis

• by P56, almost all glomeruli are sclerotic

decreased renal glomerulus number ( J:33776 , J:73660 , J:111022 )

	• at E17-E19, the nephrogenic zone contains only ~20% of the glomerular number found in control mice (J:33776) • at P0-P2, glomeruli are rarely encountered in the deep cortex (J:33776)
	• prior to P20, the number of glomeruli per unit volume cortex is ~20% of that in wild-type controls (J:111022)

renal glomerular synechia ( J:111022 )

• extensive tuft adhesions to Bowman's capsule after P20

renal glomerulus hypertrophy ( J:33776 , J:111022 )

	• at E18, only a few, but large, glomeruli are observed in the deep cortex (J:33776)
	• at P7-8, some glomeruli appear hypertrophied (J:111022) • after P8, the volume of non-sclerotic glomeruli is 4x higher than that of wild-type controls (J:111022) • by P56, non-sclerotic glomeruli are few in number and severely hypertrophied (J:111022)

abnormal kidney corticomedullary boundary morphology ( J:33776 )

• at P0-P2, the margin between the renal cortex and the medulla is indistinct, unlike in control mice

abnormal kidney development ( J:33776 )

• at E17-E19, homozygotes display inactive nephrogenesis, probably as a result of fulminant apoptosis in the mesenchyme at E13-E16

• however, initial induction of nephrons at E13 is normal

abnormal nephrogenic zone morphology ( J:33776 )

• at E17, the nephrogenic zone is thin with immature tubuli scattered among the residual uninduced mesenchyme

• at E17-E19, a 5-fold increase in the number of apoptotic cells is noted in the nephrogenic zone

• at P0-P2, the nephrogenic zone is extremely thin and consists of uninduced mesenchymal cells

abnormal renal tubule epithelium morphology ( J:73660 )

• dilated renal tubules with hypertrophic epithelium

abnormal kidney medulla morphology ( J:73660 )

• disarray of the medulla structure

small kidney ( J:33776 , J:73660 , J:111022 )

	• at P0-P2, homozygotes display smaller kidneys than wild-type or heterozygous control mice (J:33776)
	• at P7-8, mutant kidneys are smaller than wild-type (J:111022)

decreased kidney weight ( J:111022 )

• significantly reduced kidney weight from P7 to P56

• however, kidney growth rate is normal

renal hypoplasia ( J:33776 )

• homozygotes display severe renal hypoplasia

decreased nephron number ( J:33776 , J:111022 )

	• at E17-E19, homozygotes exhibit one-fifth of the nephron number found in control mice (J:33776)
	• at P7-8, nephron number is dramatically reduced (J:111022) • severe oligonephria is established at birth (J:111022)

dilated renal tubule ( J:33776 , J:73660 , J:111022 )

	• at P0-P2, several homozygotes display scattered dilatation in the lumen of renal tubules (J:33776) • dilated renal tubules with hypertrophic epithelium (J:73660)
	• after P8, hypertrophic tubules are dilated (J:111022)

renal tubule hypertrophy ( J:33776 , J:111022 )

	• at E17-E19, proximal and distal tubuli are found in the deep layer with enlargement (J:33776) • at P0-P2, renal tubuli are hypertrophic (J:33776)
	• at P7-8, some tubules appear hypertrophied (J:111022)

kidney degeneration ( J:111022 )

• after birth, kidney structural damage rapidly progresses to glomerulosclerosis and cystic renal degeneration

pale kidney ( J:73660 )

impaired branching involved in ureteric bud morphogenesis ( J:33776 )

• at E18, only rare convolution of ureteric buds is observed in the subcapsular area, unlike in control mice

• at P0-P2, ends of ureteric buds are occasionally observed in the subcapsular layer but are not convoluted

abnormal ureteric bud elongation ( J:33776 )

• at P0-P2, ureteric buds rarely extend to the subcapsular region, unlike in control mice

• neonatal UBs only extend as far as the deep layer of the kidney

small ureteric bud ( J:33776 )

• at P0-P2, ureteric buds are slender

kidney failure ( J:111022 )

• renal failure develops soon after birth

hearing/vestibular/ear

small ears ( J:73660 )

hematopoietic system

abnormal T cell differentiation ( J:73660 )

decreased lymphocyte cell number ( J:73660 )

decreased thymocyte number ( J:73660 )

decreased mature B cell number ( J:73660 )

• more than 80% reduction of B220⁺/surface immunoglobulin-positive mature B cells in the bone marrow

decreased pre-B cell number ( J:73660 )

• more than 80% reduction of B220⁺ surface immunoglobulin-negative pre-B cells in the bone marrow

decreased CD8-positive, alpha-beta T cell number ( J:73660 )

• accelerated decrease over time in the percentage of CD4-CD8+ cells in the periphery

craniofacial

round snout ( J:73660 )

• rounder nose

small ears ( J:73660 )

integument

abnormal coat/hair pigmentation ( J:73660 )

• hair color turns gray postnatally between 4 and 5 weeks, however skin is normal

cellular

increased kidney apoptosis ( J:33776 , J:111022 )

• at E13-E16, homozygotes show a 5-fold increase in nick end-labeled apoptotic cells per kidney area relative to wild-type controls (J:33776)

• at E13-E16, apoptotic cells and phagocytosed apoptotic bodies are often detected among uninduced mesenchymal cells and less frequently among induced tubular and peritubular cells (J:33776)

• at E13-E16, projections from intact mesenchymal cells are in contact with the cell membrane of apoptotic cells; in some cases, 2-3 apoptotic cells are seen together (J:33776)

• at E17-E19, homozygotes show a 5-fold increase in apoptotic cells per nephrogenic zone relative to wild-type and heterozygous controls (J:33776)

• increased kidney apoptosis throughout the tubular epithelium and the interstitium after P20 (J:111022)

• apoptosis is neither found in non-sclerotic glomeruli nor in stages prior to sclerosis (P20) (J:111022)

increased renal glomerulus apoptosis ( J:111022 )

• apoptotic bodies first seen in severely injured or sclerotic glomeruli at P20

cardiovascular system

abnormal kidney vasculature morphology ( J:111022 )

• at P13, renal arteries and veins are abnormally located immediately beneath the kidney surface

abnormal glomerular capillary endothelium morphology ( J:111022 )

• nuclear shrinkage of endothelial cells after P20

endocrine/exocrine glands

decreased thymocyte number ( J:73660 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oligomeganephronia		DOID:0111142		J:111022

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11⁺
Genetic Background	B6.129-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:73316 )

N	• mice are healthy through at least 6 months of age

pigmentation

abnormal coat/hair pigmentation ( J:73316 )

• coat color becomes gray at 5 to 7 weeks of age during completion of the second hair follicle cycle

• from the second follicle cycle on all newly grown hairs lack melanin and when an area is shaved the coat appears white suggesting the gray color is a result of unshed hairs from the first cycle

abnormal hair follicle melanocyte morphology ( J:73316 )

• by 5 to 7 weeks of age melanocytes are lost from the hair follicles

absent hair follicle melanin granules ( J:73316 )

• absent from hair starting at the second hair follicle cycle

diluted coat color ( J:73316 )

• coat colors become grey after two hair follicle cycles

• in areas where skin is shaved, hair comes back completely white

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:73316 )

N	• ear length is normal

immune system

abnormal lymphocyte physiology ( J:73316 )

• survival of mature resting T and B cells in the absence of cytokines is improved compared to cells from mice homozygous for Bcl2^tm1Dlo alone

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis

renal/urinary system

renal/urinary system phenotype ( J:73316 )

N	• mice do not develop polycystic kidney disease

integument

abnormal coat/hair pigmentation ( J:73316 )

• coat color becomes gray at 5 to 7 weeks of age during completion of the second hair follicle cycle

• from the second follicle cycle on all newly grown hairs lack melanin and when an area is shaved the coat appears white suggesting the gray color is a result of unshed hairs from the first cycle

abnormal hair follicle melanocyte morphology ( J:73316 )

• by 5 to 7 weeks of age melanocytes are lost from the hair follicles

absent hair follicle melanin granules ( J:73316 )

• absent from hair starting at the second hair follicle cycle

diluted coat color ( J:73316 )

• coat colors become grey after two hair follicle cycles

• in areas where skin is shaved, hair comes back completely white

cellular

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis

hematopoietic system

abnormal lymphocyte physiology ( J:73316 )

• survival of mature resting T and B cells in the absence of cytokines is improved compared to cells from mice homozygous for Bcl2^tm1Dlo alone

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast
Genetic Background	B6.129-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:73316 )

N	• mice are healthy through at least 6 months of age

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:73316 )

N	• ear length is normal

immune system

abnormal leukopoiesis ( J:73316 )

• irradiated mice reconstituted with mutant fetal liver cells have an increase in lymphocyte and myeloid cell numbers compared to controls

abnormal lymphocyte physiology ( J:73316 )

• survival of mature resting T and B cells in the absence of cytokines is improved compared to cells from mice homozygous for Bcl2^tm1Dlo alone and cells from wild-type mice

decreased B cell apoptosis ( J:73316 )

• about 10-fold more B cells cultured without cytokines are alive after six days compared to controls

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis over a 6 day period

renal/urinary system

renal/urinary system phenotype ( J:73316 )

N	• mice do not develop polycystic kidney disease

hematopoietic system

abnormal leukopoiesis ( J:73316 )

• irradiated mice reconstituted with mutant fetal liver cells have an increase in lymphocyte and myeloid cell numbers compared to controls

abnormal lymphocyte physiology ( J:73316 )

• survival of mature resting T and B cells in the absence of cytokines is improved compared to cells from mice homozygous for Bcl2^tm1Dlo alone and cells from wild-type mice

decreased B cell apoptosis ( J:73316 )

• about 10-fold more B cells cultured without cytokines are alive after six days compared to controls

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis over a 6 day period

integument

integument phenotype ( J:73316 )

N	• coat color is normal

cellular

decreased B cell apoptosis ( J:73316 )

• about 10-fold more B cells cultured without cytokines are alive after six days compared to controls

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis over a 6 day period

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11⁺
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

immune system

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

growth/size/body

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:153846 )

• spleens are much heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• white blood cells numbers are much higher than in homozygous Bcl-2 deficient mice

immune system

increased spleen weight ( J:153846 )

• spleens are much heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• white blood cells numbers are much higher than in homozygous Bcl-2 deficient mice

growth/size/body

increased spleen weight ( J:153846 )

• spleens are much heavier than those in homozygous Bcl-2 deficient mice

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Boui/Bcl2l11^tm1.1Boui
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Boui

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

growth/size/body

growth/size/body region phenotype ( J:153846 )

N	• grow normally

hematopoietic system

hematopoietic system phenotype ( J:153846 )

N	• normal splenic structure

immune system

immune system phenotype ( J:153846 )

N	• normal splenic structure

renal/urinary system

renal/urinary system phenotype ( J:153846 )

N	• mice do not develop polycystic kidney disease

pigmentation

diluted coat color ( J:153846 )

• coat color becomes gray at 5 to 7 weeks of age

integument

diluted coat color ( J:153846 )

• coat color becomes gray at 5 to 7 weeks of age

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Boui/Bcl2l11^tm2.1Boui
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Boui/Bcl2l11^tm2.1Boui

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2l11^tm2.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

hematopoietic system

hematopoietic system phenotype ( J:153846 )

N	• normal splenic structure

increased spleen weight ( J:153846 )

• spleens are much heavier than those in homozygous Bcl-2 deficient mice

• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice

increased leukocyte cell number ( J:153846 )

• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

renal/urinary system

renal/urinary system phenotype ( J:153846 )

N	• mice do not develop polycystic kidney disease

immune system

immune system phenotype ( J:153846 )

N	• normal splenic structure

increased spleen weight ( J:153846 )

• spleens are much heavier than those in homozygous Bcl-2 deficient mice

• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice

increased leukocyte cell number ( J:153846 )

• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

growth/size/body

increased spleen weight ( J:153846 )

• spleens are much heavier than those in homozygous Bcl-2 deficient mice

• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm2.1Boui/Bcl2l11^tm2.1Boui
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm2.1Boui

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm2.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

growth/size/body

growth/size/body region phenotype ( J:153846 )

N	• grow normally

hematopoietic system

hematopoietic system phenotype ( J:153846 )

N	• normal splenic structure

immune system

immune system phenotype ( J:153846 )

N	• normal splenic structure

renal/urinary system

renal/urinary system phenotype ( J:153846 )

N	• mice do not develop polycystic kidney disease diluted coat color [MP:0000371]

pigmentation

diluted coat color ( J:153846 )

• coat color becomes gray at 5 to 7 weeks of age

integument

diluted coat color ( J:153846 )

• coat color becomes gray at 5 to 7 weeks of age

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm3.1Boui/Bcl2l11^tm3.1Boui
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm3.1Boui

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm3.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The Bcl2l11^tm3.1Boui mutation ameliorates the degenerative disorders of Bcl2^tm1Dlo/Bcl2^tm1Dlo mice

mortality/aging

premature death ( J:153846 )

• live up to 300 days due to mild polycystic kidney disease (PKD)

growth/size/body

polycystic kidney ( J:153846 )

• mild signs of polycystic kidney disease (PKD)

• progress slowly

• live up to 300 days

postnatal growth retardation ( J:153846 )

• retarded growth

• most of these animals (n = 24) become healthy adults

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

hematopoietic system

hematopoietic system phenotype ( J:153846 )

N	• normal splenic structure

decreased splenocyte apoptosis ( J:153846 )

• less apoptosis than in homozygous Bcl-2 deficient mice spleen

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

renal/urinary system

polycystic kidney ( J:153846 )

• mild signs of polycystic kidney disease (PKD)

• progress slowly

• live up to 300 days

immune system

immune system phenotype ( J:153846 )

N	• normal splenic structure

decreased splenocyte apoptosis ( J:153846 )

• less apoptosis than in homozygous Bcl-2 deficient mice spleen

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

cellular

decreased splenocyte apoptosis ( J:153846 )

• less apoptosis than in homozygous Bcl-2 deficient mice spleen

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bik^tm1Ast/Bik^tm1Ast
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bik^tm1Ast

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)
Bik^tm1Ast mutation (1 available); any Bik mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:104487 )

• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age

growth/size/body

polycystic kidney ( J:104487 )

• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age

decreased body size ( J:104487 )

• all homozygotes become runted

immune system

abnormal lymphocyte physiology ( J:104487 )

• survival of mature resting T and B cells in the absence of cytokines is impaired compared to wild-type cells and similar to mice homozygous for Bcl2^tm1Dlo alone

renal/urinary system

polycystic kidney ( J:104487 )

• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age

hematopoietic system

abnormal lymphocyte physiology ( J:104487 )

• survival of mature resting T and B cells in the absence of cytokines is impaired compared to wild-type cells and similar to mice homozygous for Bcl2^tm1Dlo alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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