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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam3tm1Pmkf
targeted mutation 1, Paul Primakoff
MGI:2156167
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam3tm1Pmkf/Adam3tm1Pmkf Not Specified MGI:2665309
cx2
 		Adam2tm1Dgm/Adam2tm1Dgm
Adam3tm1Pmkf/Adam3tm1Pmkf 		involves: C57BL/6N MGI:3039874


Genotype
MGI:2665309
hm1
Allelic
Composition		 Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam3tm1Pmkf mutation (1 available); any Adam3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
male infertility ( J:69282 )
• males are 100% infertile
• however, sperm number, morphology, motility and rate of acrosome reaction are normal
impaired fertilization ( J:69282 )
• sperm binding to the egg plasma membrane is reduced, however mutant sperm fuse with the plasma membrane with the same fertilization rate as wild-type sperm
impaired binding of sperm to zona pellucida ( J:69282 )
• sperm cannot bind to the zona pellucida




Genotype
MGI:3039874
cx2
Allelic
Composition		 Adam2tm1Dgm/Adam2tm1Dgm
Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam2tm1Dgm mutation (1 available); any Adam2 mutation (42 available)
Adam3tm1Pmkf mutation (1 available); any Adam3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:69282 )
• the ability of sperm from mutant mice to bind to and fuse with eggs is reduced to the same extent as in either single knock out mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory