About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpc3Gt(Ex136)Byg
gene trap Ex136, BayGenomics
MGI:2156194
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpc3Gt(Ex136)Byg/Gpc3Gt(Ex136)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3826409
ht2
 		Gpc3Gt(Ex136)Byg/Gpc3+ involves: 129P2/OlaHsd * C57BL/6 MGI:3849593
cx3
 		Bmp4tm1Blh/Bmp4+
Gpc3Gt(Ex136)Byg/Y 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3849594
ot4
 		Gpc3Gt(Ex136)Byg/Y involves: 129P2/OlaHsd * C57BL/6 MGI:3849592


Genotype
MGI:3826409
hm1
Allelic
Composition		 Gpc3Gt(Ex136)Byg/Gpc3Gt(Ex136)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
increased embryo size ( J:70273 )
• embryonic overgrowth
kidney cyst ( J:70273 )

renal/urinary system

embryo
increased embryo size ( J:70273 )
• embryonic overgrowth




Genotype
MGI:3849593
ht2
Allelic
Composition		 Gpc3Gt(Ex136)Byg/Gpc3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
abnormal ventral body wall morphology ( J:64330 )
• ventral wall closure defects with incomplete penetrance
• usually results in small to moderate umbilical hernias
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia
increased body size ( J:64330 )
• males are 30% larger than controls
• females show intermediate growth properties

renal/urinary system
abnormal kidney medulla morphology ( J:64330 )
• medullary cystic dysplasia
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia

skeleton
split xiphoid process ( J:64330 )
• bifurcated

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Simpson-Golabi-Behmel syndrome type 1 DOID:0060248 OMIM:312870
 J:64330




Genotype
MGI:3849594
cx3
Allelic
Composition		 Bmp4tm1Blh/Bmp4+
Gpc3Gt(Ex136)Byg/Y
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (23 available)
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:64330 )
• bifurcated 5th digits frequently seen on forelimbs
• ectopic triphalangeal duplications branching from the 5th metatarsal
• 66% show show similar branched bifurcation of the right 5th digit of the hind limb

skeleton
abnormal sternum ossification ( J:64330 )
• dual ossification centers along the length of the sternum




Genotype
MGI:3849592
ot4
Allelic
Composition		 Gpc3Gt(Ex136)Byg/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:64330 )
• normal numbers of hemizygotes at E16.5
• hemizygotes reduced from 26% to 16% by weaning

growth/size/body
abnormal ventral body wall morphology ( J:64330 )
• ventral wall closure defects with incomplete penetrance
• usually results in small to moderate umbilical hernias
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia
increased body size ( J:64330 )
• males are 30% larger than controls
• females show intermediate growth properties

renal/urinary system
abnormal kidney medulla morphology ( J:64330 )
• medullary cystic dysplasia
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia

skeleton
split xiphoid process ( J:64330 )
• bifurcated

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Simpson-Golabi-Behmel syndrome type 1 DOID:0060248 OMIM:312870
 J:64330




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory