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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpc3Gt(Ex136)Byg
gene trap Ex136, BayGenomics
MGI:2156194
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpc3Gt(Ex136)Byg/Gpc3Gt(Ex136)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3826409
ht2
 		Gpc3Gt(Ex136)Byg/Gpc3+ involves: 129P2/OlaHsd * C57BL/6 MGI:3849593
cx3
 		Bmp4tm1Blh/Bmp4+
Gpc3Gt(Ex136)Byg/Y 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3849594
ot4
 		Gpc3Gt(Ex136)Byg/Y involves: 129P2/OlaHsd * C57BL/6 MGI:3849592


Genotype
MGI:3826409
hm1
Allelic
Composition		 Gpc3Gt(Ex136)Byg/Gpc3Gt(Ex136)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
increased embryo size ( J:70273 )
• embryonic overgrowth
kidney cyst ( J:70273 )

renal/urinary system

embryo
increased embryo size ( J:70273 )
• embryonic overgrowth




Genotype
MGI:3849593
ht2
Allelic
Composition		 Gpc3Gt(Ex136)Byg/Gpc3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
abnormal ventral body wall morphology ( J:64330 )
• ventral wall closure defects with incomplete penetrance
• usually results in small to moderate umbilical hernias
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia
increased body size ( J:64330 )
• males are 30% larger than controls
• females show intermediate growth properties

renal/urinary system
abnormal kidney medulla morphology ( J:64330 )
• medullary cystic dysplasia
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia

skeleton
split xiphoid process ( J:64330 )
• bifurcated

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Simpson-Golabi-Behmel syndrome type 1 DOID:0060248 OMIM:312870
 J:64330




Genotype
MGI:3849594
cx3
Allelic
Composition		 Bmp4tm1Blh/Bmp4+
Gpc3Gt(Ex136)Byg/Y
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (23 available)
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:64330 )
• bifurcated 5th digits frequently seen on forelimbs
• ectopic triphalangeal duplications branching from the 5th metatarsal
• 66% show show similar branched bifurcation of the right 5th digit of the hind limb

skeleton
abnormal sternum ossification ( J:64330 )
• dual ossification centers along the length of the sternum




Genotype
MGI:3849592
ot4
Allelic
Composition		 Gpc3Gt(Ex136)Byg/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:64330 )
• normal numbers of hemizygotes at E16.5
• hemizygotes reduced from 26% to 16% by weaning

growth/size/body
abnormal ventral body wall morphology ( J:64330 )
• ventral wall closure defects with incomplete penetrance
• usually results in small to moderate umbilical hernias
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia
increased body size ( J:64330 )
• males are 30% larger than controls
• females show intermediate growth properties

renal/urinary system
abnormal kidney medulla morphology ( J:64330 )
• medullary cystic dysplasia
kidney medulla cyst ( J:64330 )
• medullary cystic dysplasia

skeleton
split xiphoid process ( J:64330 )
• bifurcated

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Simpson-Golabi-Behmel syndrome type 1 DOID:0060248 OMIM:312870
 J:64330




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory