All Phenotypes Sema6a<Gt(KST069)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd	MGI:3795751
hm2	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6J	MGI:3037891
cn3	Chat^tm2(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr	MGI:5562538
cx4	Plxna4^tm1Matl/Plxna4⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺	involves: 129P2/OlaHsd	MGI:5007634
cx5	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Sema6b^tm1Hfu/Sema6b^tm1Hfu	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:4461294
cx6	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795752
cx7	Plxna2^tm1Hfu/Plxna2⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3795755
cx8	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	MGI:5562540
cx9	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Tg(Trhr-EGFP)HU193Gsat/0	involves: 129P2/OlaHsd * FVB/NTac	MGI:5562539

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:172268 , J:202884 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice (J:172268)

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other (J:202884)

• On SACs are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes (J:202884)

• On SACs have asymmetric dendritic arbors; however, Off cells develop the normal radially symmetrical dendritic pattern (J:202884)

• disruption of the dendritic plexus organization of On but not Off SACs (J:202884)

abnormal retina ganglion cell morphology ( J:172268 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

nervous system phenotype ( J:135421 )

N	• unlike mice homozygous for Plxna4^tm1Hfu no obvious abnormalities in mossy fiber projection are seen

abnormal hippocampal mossy fiber morphology ( J:160509 )

• mice exhibit abnormal projection of mossy cell axons compared to in wild-type mice

• however, the thickness of the suprapyramidal bundle is normal

abnormal neurite morphology ( J:172268 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice

abnormal dendrite morphology ( J:202884 )

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

• disruption of the dendritic plexus organization of On but not Off SACs

abnormal amacrine cell morphology ( J:172268 , J:202884 )

• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other (J:202884)

• On SACs are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes (J:202884)

• On SACs have asymmetric dendritic arbors; however, Off cells develop the normal radially symmetrical dendritic pattern (J:202884)

• disruption of the dendritic plexus organization of On but not Off SACs (J:202884)

abnormal retina ganglion cell morphology ( J:172268 )

• dopaminergic amacrine cells, M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs), and calbindin+ cells exhibit abnormal neurite stratification compared with wild-type mice

Allelic Composition	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:67920 )

N	• no behavioral abnormalities are observed

reproductive system

reproductive system phenotype ( J:67920 )

N	• homozygotes are viable and fertile

nervous system

abnormal forebrain morphology ( J:67920 )

• rostral thalamocortical axons project normally

• caudal thalamocortical axons project down toward the amygdala rather than up toward the cortex

Allelic Composition	Chat^tm2(cre)Lowl/Chat⁺ Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (58 available)
Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze} mutation (4 available); any Gt(ROSA)26Sor mutation (993 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:202884 )

• starburst amacrine cells in flat mount retinas show excess and aberrant light-evoked inhibitory postsynaptic currents

Allelic Composition	Plxna4^tm1Matl/Plxna4⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4^tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased sensory neuron number ( J:172268 )

• mice exhibit an increase in TH+ puncta in S4/S5 of the inner plexiform layer compared to in wild-type mice

Allelic Composition	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Sema6b^tm1Hfu/Sema6b^tm1Hfu
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)
Sema6b^tm1Hfu mutation (0 available); any Sema6b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:160509 )

• the suprapyramidal bundle is thicker and the infrapyramidal bundle is longer than in Sema6b^tm1Hfu homozygotes

• more mossy fibers aberrantly spread into the stratum radiatum and stratum oriens compared to in Sema6b^tm1Hfu homozygotes

• however, mossy fiber spread into the stratum lacunosum-moleculare is normal

• mossy fibers invade the inner molecular layer of the dentate gyrus unlike in wild-type mice

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2^tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:135421 )

N	• unlike mice homozygous for Plxna2^tm1Hfu alone mossy fiber projection is essentially normal

abnormal hippocampal mossy fiber morphology ( J:160509 )

• the suprapyramidal bundle is slightly thinner than in wild-type mice

ectopic cerebellar granule cells ( J:135408 )

• the number of ectopic granule cells in the molecular layer is not significantly different from single homozygous mice

Allelic Composition	Plxna2^tm1Hfu/Plxna2⁺ Sema6a^{Gt(KST069)Byg}/Sema6a⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

ectopic cerebellar granule cells ( J:135408 )

• in the molecular layer

Allelic Composition	Plxna2^tm1Hfu/Plxna2^tm1Hfu Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

abnormal retina inner plexiform layer morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system

abnormal dendrite morphology ( J:202884 )

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

abnormal amacrine cell morphology ( J:202884 )

• the starburst amacrine cell processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

• On starburst amacrine cells are missing extensive portions of their dendritic fields and normal dendritic self-avoidance is compromised in the distal most third of the dendritic processes

Allelic Composition	Sema6a^{Gt(KST069)Byg}/Sema6a^{Gt(KST069)Byg} Tg(Trhr-EGFP)HU193Gsat/0
Genetic Background	involves: 129P2/OlaHsd * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6a^{Gt(KST069)Byg} mutation (1 available); any Sema6a mutation (85 available)
Tg(Trhr-EGFP)HU193Gsat mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal single cell response ( J:202884 )

• cell patch recording of direction-selective ganglion cells presented with drifting-bar motion stimulation show that On direction-selective tuning is compromised; however, Off response is similar to controls

• On responses have abnormal, broader, directional tuning, with the magnitudes of the response vector sums being significantly lower

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24