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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		AtrnGt(PST112)Byg
gene trap PST112, BayGenomics
MGI:2156204
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		AtrnGt(PST112)Byg/AtrnGt(PST112)Byg C3.129P2-AtrnGt(PST112)Byg MGI:3773152
hm2
 		AtrnGt(PST112)Byg/AtrnGt(PST112)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3697746
cx3
 		AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Tg(ACTB-Atrnl1)B4Tmg/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3773153


Genotype
MGI:3773152
hm1
Allelic
Composition		 AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic
Background		 C3.129P2-AtrnGt(PST112)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AtrnGt(PST112)Byg mutation (0 available); any Atrn mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:130463 )
• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months
• mild to moderate vacuolation occurs at 6 months
• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background
abnormal myelination ( J:130463 )
• mice exhibit hypomyelination

pigmentation
darkened coat color ( J:130463 )
• unlike homozygotes, mice display a wild-type coat color

integument
darkened coat color ( J:130463 )
• unlike homozygotes, mice display a wild-type coat color




Genotype
MGI:3697746
hm2
Allelic
Composition		 AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AtrnGt(PST112)Byg mutation (0 available); any Atrn mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:70273 )
• mahogany coat color

integument
darkened coat color ( J:70273 )
• mahogany coat color




Genotype
MGI:3773153
cx3
Allelic
Composition		 AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Tg(ACTB-Atrnl1)B4Tmg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AtrnGt(PST112)Byg mutation (0 available); any Atrn mutation (89 available)
Tg(ACTB-Atrnl1)B4Tmg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:130463 )
• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months
• mild to moderate vacuolation occurs at 6 months
• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background
abnormal myelination ( J:130463 )
• hypomyelination observed in homozygotes is partially rescued

integument
integument phenotype ( J:130463 )
N
• unlike homozygotes, mice display a wild-type coat color




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory