Analysis Tools
cellular
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• after 4 days under differentiating conditions in culture, hippocampal progenitor cells from null mice show a 1.9-fold increase in cells expressing differentiation markers compared to wild-type cells
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• null mice show a 37% increase in granule cell layer neuron density and 15% increase in GCL density
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• a 1.4-fold increase in labeled cells is detected in mutants either 1 day or 4 weeks after BrdU treatment; 1 hour after a single BrdU injection, a 3.3-fold increase in labeled cells is observed in mutants versus wild-type
• hippocampal cultures from E16-17 null mice exhibit a 2.1-fold increase in the percentage of proliferating cells
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nervous system
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• null mice show a 37% increase in granule cell layer neuron density and 15% increase in GCL density
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