Phenotypes associated with this allele

• Allele Symbol: Il12rb2^Ifnm-d
• Allele Name: interferon response to microorgansisms, defective
• Allele ID: MGI:2156401
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il12rb2^Ifnm-d/Il12rb2^Ifnm-d Tlr4^lps-del/Tlr4^lps-del	C57BL/10ScCr	MGI:3603338

Genotype
MGI:3603338

cx1

• Allelic Composition: Il12rb2^Ifnm-d/Il12rb2^Ifnm-d; Tlr4^lps-del/Tlr4^lps-del
• Genetic Background: C57BL/10ScCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune cell physiology ( J:91014 )

abnormal granulocyte physiology ( J:91014 )

• increased infiltration at sites of infection

abnormal NK cell physiology ( J:91014 )

• increased infiltration at sites of infection

abnormal macrophage physiology ( J:91014 )

• increased infiltration at sites of infection

abnormal dendritic cell physiology ( J:91014 )

• increased infiltration of myeloid derived dendritic cells at infection sites

decreased interferon-gamma secretion ( J:70821 , J:91014 )

• inability or reduced ability to produce IFN gamma in response to bacterial infection (J:91014)

increased interleukin-4 secretion ( J:91014 )

• elevated Il4 production

increased susceptibility to bacterial infection ( J:70821 , J:91014 )

• defective response to lipopolysaccharide (J:70821)

• unable to resolve Leishmania major infections (J:91014)

• develop nonhealing lesions by 33 days after infection (J:91014)

• formation of lesions slower after infection (J:91014)

• develop higher parasite loads at sites of infection (J:91014)

hematopoietic system

abnormal granulocyte physiology ( J:91014 )

• increased infiltration at sites of infection

abnormal NK cell physiology ( J:91014 )

• increased infiltration at sites of infection

abnormal macrophage physiology ( J:91014 )

• increased infiltration at sites of infection