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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il7tm1Hms
targeted mutation 1, Harvard Medical School
MGI:2156458
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il7tm1Hms/Il7tm1Hms involves: 129S6/SvEvTac MGI:2668582


Genotype
MGI:2668582
hm1
Allelic
Composition		 Il7tm1Hms/Il7tm1Hms
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7tm1Hms mutation (2 available); any Il7 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:43971 )
• thymocyte number is 1-5% of wild-type littermates
decreased bone marrow cell number ( J:43971 )
• cell number approximately half of wild-type littermates due to a deficit in B cell lineage cells
spleen hypoplasia ( J:43971 )
• splenic lymphocyte number is less than half of wild-type littermates

immune system
thymus hypoplasia ( J:43971 )
• thymocyte number is 1-5% of wild-type littermates
spleen hypoplasia ( J:43971 )
• splenic lymphocyte number is less than half of wild-type littermates

endocrine/exocrine glands
thymus hypoplasia ( J:43971 )
• thymocyte number is 1-5% of wild-type littermates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory