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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdc42tm1Fwa
targeted mutation 1, Fredrick W Alt
MGI:2156460
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdc42tm1Fwa/Cdc42tm1Fwa involves: 129S6/SvEvTac MGI:3848920


Genotype
MGI:3848920
hm1
Allelic
Composition
Cdc42tm1Fwa/Cdc42tm1Fwa
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Fwa mutation (0 available); any Cdc42 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous embryos at E7.5
• mostly degenerated at E6.5
• blastocysts visibly normal at E3.5

embryo
• embryos at E5.5 are smaller than normal
• embryonic primary ectoderm largely lacking at E5.5

cellular
• actin structures in homozygous ES cells are diffuse and disorganized

growth/size/body
• embryos at E5.5 are smaller than normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory