Phenotypes associated with this allele

• Allele Symbol: Epha4^tm2Kln
• Allele Name: targeted mutation 2, Rudiger Klein
• Allele ID: MGI:2156479
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha4^tm2Kln/Epha4^tm2Kln	involves: 129P2/OlaHsd * C57BL/6	MGI:3608666
ht2	Epha4^tm2Kln/Epha4^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3694677

Genotype
MGI:3608666

hm1

• Allelic Composition: Epha4^tm2Kln/Epha4^tm2Kln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:67274 , J:101019 )

• hopping gait (J:101019)

nervous system

abnormal primary somatosensory cortex morphology ( J:115279 )

abnormal barrel cortex morphology ( J:115279 )

abnormal innervation ( J:115279 )

• 55% of mice display abnormal thalamocortical (TC) projections from the ventro-posterior-medial (VPM) part of the ventro-basal nucleus (VB) to the primary somatosensory area S1, with cells located at ectopic positions with respect to the position corresponding to normal barreloid clusters

abnormal spinal cord dorsal column morphology ( J:101019 )

• the dorsoventral extent of the dorsal funiculus is reduced and fibers within the dorsal funiculus re-cross the midline at the lumbar level

Genotype
MGI:3694677

ht2

• Allelic Composition: Epha4^tm2Kln/Epha4⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal primary somatosensory cortex morphology ( J:115279 )

abnormal barrel cortex morphology ( J:115279 )

abnormal innervation ( J:115279 )

• 30% of heterozygotes show similar abnormalities in TC to homozygotes