growth/size/body
• heterozygous mice are smaller than wild-type or recombinase expressing controls but larger than homozygous mice
|
skeleton
• smaller appendicular elements, intermediate to homozygous mice
|
• smaller axial elements, intermediate to homozygous mice
|
• mid-diaphyseal cortical bone is smaller in width but not reduced in thickness
|
• osteogenic capacity of bone marrow stem cells is absent in vitro
|