Phenotypes associated with this allele

• Allele Symbol: Agtr1a^tm1Afu
• Allele Name: targeted mutation 1, Akiyoshi Fukamizu
• Allele ID: MGI:2156487
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agtr1a^tm1Afu/Agtr1a^tm1Afu	involves: C57BL/6 * CBA	MGI:3047404
hm2	Agtr1a^tm1Afu/Agtr1a^tm1Afu	involves: C57BL/6 * CBA * ICR	MGI:3618297
ht3	Agtr1a^tm1Afu/Agtr1a^+	involves: C57BL/6 * CBA * ICR	MGI:3618298
cx4	Agtr1a^tm1Afu/Agtr1a^tm1Afu Agtr2^tm1Gsb/Y	mixed	MGI:3639148

Genotype
MGI:3047404

hm1

• Allelic Composition: Agtr1a^tm1Afu/Agtr1a^tm1Afu
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypotension ( J:91164 )

• double homozygotes are hypotensive compared to wild-type, however blood pressure is increased compared to Agtr1^tm1Afu homozygotes

homeostasis/metabolism

decreased susceptibility to injury ( J:100334 )

• mice exposed to acid aspiration to induce acute lung injury show improved lung function, reduced edema formation, and greatly attenuated pulmonary vascular permeability compared to wild-type control

renal/urinary system

abnormal kidney interstitium morphology ( J:69294 )

• reduced interstitial volume

Genotype
MGI:3618297

hm2

• Allelic Composition: Agtr1a^tm1Afu/Agtr1a^tm1Afu
• Genetic Background: involves: C57BL/6 * CBA * ICR

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:28041 , J:107851 )

• homozygotes display a 22 mm Hg reduction in systolic blood pressure (77% of wild-type values) (J:28041)

• after central injection of angiotensin II, adult male homozygotes exhibit a significantly smaller increase in SBP than wild-type males within the range of 50-200 ng, with no differences in the time course of the pressor response; no obvious dose dependence is observed, although a dose of 200 ng results in a slightly increased SBP (J:107851)

• i.c.v. injection of angiotensin II (100 ng) has no effect on SBP in male homozygotes; also, PD-123319 does not significantly change BP after central injection of angiotensin II (J:107851)

hypotension ( J:28041 )

• homozygotes exhibit chronic hypotension, with a significant decline in both the systolic and diastolic blood pressure relative to wild-type mice

homeostasis/metabolism

increased circulating renin level ( J:28041 )

• homozygotes display hyperreninemia, with a 7- to 8-fold elevation in the plasma concentration of active renin relative to wild-type and heterozygous mutant mice

increased renin activity ( J:28041 )

• homozygotes show a significant increase in renin mRNA levels in the kidney and in plasma renin activity relative to wild-type mice

behavior/neurological

increased fluid intake ( J:107851 )

• i.c.v injection of angiotensin II (100 ng) increases water intake 5-fold in adult wild-type males; this increase is reduced by ~60% in adult male homozygotes relative to wild-type males

• in wild-type males, the effect of angiotensin II on water intake is significantly inhibited by valsartan and by PD-123319; in male homozygotes this effect is suppressed by ~40% by PD-123319 but not valsartan

Genotype
MGI:3618298

ht3

• Allelic Composition: Agtr1a^tm1Afu/Agtr1a⁺
• Genetic Background: involves: C57BL/6 * CBA * ICR

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:28041 )

• heterozygotes display a 10 mm Hg reduction in systolic blood pressure relative to wild-type mice

hypotension ( J:28041 )

• heterozygotes exhibit chronic hypotension, with a significant decline in both the systolic and diastolic blood pressure relative to wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:28041 )

N • heterozygotes show no significant differences in renin mRNA levels in the kidney or in plasma renin activity relative to wild-type mice

Genotype
MGI:3639148

cx4

• Allelic Composition: Agtr1a^tm1Afu/Agtr1a^tm1Afu; Agtr2^tm1Gsb/Y
• Genetic Background: mixed

behavior/neurological

increased fluid intake ( J:107851 )

♂ • i.c.v injection of angiotensin II (100 ng) increases water intake 5-fold in adult wild-type males but has no significant effect on water intake in males homozygous for Agtr1a^tm1Afu and hemizygous for Agtr2^tm1Gsb

cardiovascular system

abnormal systemic arterial blood pressure ( J:107851 )

♂ • adult males homozygous for Agtr1a^tm1Afu and hemizygous for Agtr2^tm1Gsb show no apparent physiological changes (e.g. body weight gain) or histological abnormalities in the heart, artery or brain

♂ • however, these mice display a higher increase in SBP after central injection of a high dose of angiotensin II (200 ng) relative to Agtr1a^tm1Afu homozygotes