Analysis Tools
immune system
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• following topical arachidonic acid application, ear biopsies from mutant mice display significantly decreased MPO levels, reflecting reduced recruitment of neutrophils to the treated tissue
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• homozygotes show a reduced acute inflammatory response to topical arachidonic acid, as shown by reduced ear edema and decreased vascular permeability and extravasation of serum proteins relative to wild-type mice
• in contrast, homozygotes exhibit a normal delayed-type hypersensitivity response to cutaneous FITC, and normal passive systemic IgE-induced anaphylaxis (as measured by edema formation and temperature changes)
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homeostasis/metabolism
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• in culture, mutant peritoneal macrophages fail to produce detectable LTC4 levels following Ca2+-ionophore stimulation
• in vivo, homozygotes fail to produce detectable LTC4 levels following zymosan A-induced peritonitis
• in addition, homozygotes exhibit significantly reduced leukotriene-dependent edema formation following zymosan A-induced peritonitis
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• in culture, mutant peritoneal macrophages produce significantly increased prostaglandin E2 levels following Ca2+-ionophore stimulation
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• in culture, mutant peritoneal macrophages produce increased TXB2 levels following Ca2+-ionophore stimulation; however, this difference does not reach statistical significance
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hematopoietic system
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• following topical arachidonic acid application, ear biopsies from mutant mice display significantly decreased MPO levels, reflecting reduced recruitment of neutrophils to the treated tissue
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