All Phenotypes Amhr2<tm1Bhr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Amhr2^tm1Bhr
targeted mutation 1, Richard R Behringer
MGI:2156555

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amhr2^tm1Bhr/Amhr2^tm1Bhr	involves: 129S7/SvEvBrd	MGI:3042182
hm2	Amhr2^tm1Bhr/Amhr2^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3042181
cx3	Amhr2^tm1Bhr/Amhr2^tm1Bhr Inha^tm1Bay/Inha^tm1Bay	involves: 129S7/SvEvBrd	MGI:3042187
cx4	Amhr2^tm1Bhr/Amhr2^tm1Bhr Inha^tm1Bay/Inha⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3042188
cx5	Amh^tm1Bhr/Amh⁺ Amhr2^tm1Bhr/Amhr2^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:3042189
cx6	Amh^tm1Bhr/Amh^tm1Bhr Amhr2^tm1Bhr/Amhr2^tm1Bhr	Not Specified	MGI:3042185

Allelic Composition	Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm1Bhr mutation (0 available); any Amhr2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

seminiferous tubule degeneration ( J:36027 )

• focal atrophy of the germinal epithelium by 2 months of age

increased Leydig cell number ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

reproductive system

reproductive system phenotype ( J:36027 )

N	• female mice developed, exhibited normal folliculogenesis and germ cell development, and were fertile

abnormal Sertoli cell morphology ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

seminiferous tubule degeneration ( J:36027 )

• focal atrophy of the germinal epithelium by 2 months of age

increased Leydig cell number ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

male pseudohermaphroditism ( J:36027 )

• males developed Mullerian duct derivatives, including a uterus, oviducts, and a partial vagina that were superimposed upon the male reproductive system

• male mice had testes of normal size that were properly descended into the scrotal sac

• normal differentiation of male-specific Wolffian duct-derived tissue

secondary sex reversal ( J:36027 )

male infertility ( J:36027 )

• spermatogenesis was unimpaired and sperm was produced, however some males were infertile due to the presence of female reproductive organs that blocked sperm transfer

reduced male fertility ( J:36027 )

• some male mice sired offspring, however fewer litters relative to controls

embryo

failure of Mullerian duct regression ( J:171430 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
persistent Mullerian duct syndrome		DOID:0050791	OMIM:261550	J:171430

Allelic Composition	Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm1Bhr mutation (0 available); any Amhr2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

seminiferous tubule degeneration ( J:36027 )

• focal atrophy of the germinal epithelium by 2 months of age

increased Leydig cell number ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

reproductive system

reproductive system phenotype ( J:36027 )

N	• female mice developed, exhibited normal folliculogenesis and germ cell development, and were fertile

abnormal Sertoli cell morphology ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

seminiferous tubule degeneration ( J:36027 )

• focal atrophy of the germinal epithelium by 2 months of age

increased Leydig cell number ( J:36027 )

• observed in areas of focal seminiferous tubule degeneration

male pseudohermaphroditism ( J:36027 )

• males developed Mullerian duct derivatives, including a uterus, oviducts, and a partial vagina that were superimposed upon the male reproductive system

• male mice had testes of normal size that were properly descended into the scrotal sac

• normal differentiation of male-specific Wolffian duct-derived tissue

secondary sex reversal ( J:36027 )

male infertility ( J:36027 )

• spermatogenesis was unimpaired and sperm was produced, however some males were infertile due to the presence of female reproductive organs that blocked sperm transfer

reduced male fertility ( J:36027 )

• some male mice sired offspring, however fewer litters relative to controls

Allelic Composition	Amhr2^tm1Bhr/Amhr2^tm1Bhr Inha^tm1Bay/Inha^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm1Bhr mutation (0 available); any Amhr2 mutation (29 available)
Inha^tm1Bay mutation (0 available); any Inha mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:36027 )

• multifocal Sertoli/granulosa cell tumors

increased granulosa cell tumor incidence ( J:36027 )

• multifocal granulosa cell tumors

increased testis tumor incidence ( J:36027 )

• testicular tumors, larger than those observed in Inha-deficient mice

increased Leydig cell tumor incidence ( J:36027 )

• Leydig cell neoplasia

reproductive system

increased granulosa cell tumor incidence ( J:36027 )

• multifocal granulosa cell tumors

increased testis tumor incidence ( J:36027 )

• testicular tumors, larger than those observed in Inha-deficient mice

increased Leydig cell tumor incidence ( J:36027 )

• Leydig cell neoplasia

dilated uterus ( J:36027 )

• the uteri observed in male pseudohermaphrodites were dilated and fluid-filled

male pseudohermaphroditism ( J:36027 )

secondary sex reversal ( J:36027 )

endocrine/exocrine glands

increased granulosa cell tumor incidence ( J:36027 )

• multifocal granulosa cell tumors

increased testis tumor incidence ( J:36027 )

• testicular tumors, larger than those observed in Inha-deficient mice

increased Leydig cell tumor incidence ( J:36027 )

• Leydig cell neoplasia

Allelic Composition	Amhr2^tm1Bhr/Amhr2^tm1Bhr Inha^tm1Bay/Inha⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

reproductive system

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

male pseudohermaphroditism ( J:36027 )

secondary sex reversal ( J:36027 )

endocrine/exocrine glands

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

Allelic Composition	Amh^tm1Bhr/Amh⁺ Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm1Bhr mutation (0 available); any Amhr2 mutation (29 available)
Amh^tm1Bhr mutation (2 available); any Amh mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

reproductive system

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

male pseudohermaphroditism ( J:36027 )

secondary sex reversal ( J:36027 )

endocrine/exocrine glands

increased testis tumor incidence ( J:36027 )

• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

Allelic Composition	Amh^tm1Bhr/Amh^tm1Bhr Amhr2^tm1Bhr/Amhr2^tm1Bhr
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:36027 )

N	• female mice developed normally and were fertile

male pseudohermaphroditism ( J:36027 )

• males developed Mullerian duct derivatives

• male mice had testes of normal size that were properly descended into the scrotal sac

• normal differentiation of male-specific Wolffian duct-derived tissue

secondary sex reversal ( J:36027 )

male infertility ( J:36027 )

• spermatogenesis was unimpaired, however males were infertile due to the presence of female reproductive organs that blocked sperm transfer

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