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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pas17C57BL/6JBy
C57BL/6JBy
MGI:2156574
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pas17C57BL/6JBy/Pas17C57BL/6JBy
Politm1.1Lgh/Poli+ 		involves: C57BL/6J MGI:5582778
cx2
 		Pas17C57BL/6JBy/Pas17C57BL/6JBy
Politm1.1Lgh/Politm1.1Lgh 		involves: C57BL/6J MGI:5582779


Genotype
MGI:5582778
cx1
Allelic
Composition		 Pas17C57BL/6JBy/Pas17C57BL/6JBy
Politm1.1Lgh/Poli+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pas17C57BL/6JBy mutation (0 available); any Pas17 mutation (0 available)
Politm1.1Lgh mutation (0 available); any Poli mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:212610 )
• intermediate increase in tumor number induced by urethane
• however, tumor size is normal

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:212610 )
• intermediate increase in tumor number induced by urethane
• however, tumor size is normal




Genotype
MGI:5582779
cx2
Allelic
Composition		 Pas17C57BL/6JBy/Pas17C57BL/6JBy
Politm1.1Lgh/Politm1.1Lgh
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pas17C57BL/6JBy mutation (0 available); any Pas17 mutation (0 available)
Politm1.1Lgh mutation (0 available); any Poli mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:212610 )
• increase in tumor number induced by urethane that is not as severe as in mice heterozygous for Par2A/J, Politm1Lgh, and Pas1A/J/Pas1C57BL/6J
• however, tumor size is normal

cellular
abnormal cell physiology ( J:212610 )
• increased urethane-induced DNA mutations in Kras

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:212610 )
• increase in tumor number induced by urethane that is not as severe as in mice heterozygous for Par2A/J, Politm1Lgh, and Pas1A/J/Pas1C57BL/6J
• however, tumor size is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory