Analysis Tools|
Allele Symbol Allele Name Allele ID |
Trp53tm1.1Brn targeted mutation 1.1, Anton Berns MGI:2156651 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a similar increase in tumor incidence with the same spectrum as in other Trp53 null mice
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• median tumor-free survival is 116 days compared to 515 in heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in all mice treated with a cre-expressing adenovirus
(J:86077)
• in 6 of 7 mice following treatment with cre-expressing adenovirus
(J:157319)
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• in all mice treated with a cre-expressing adenovirus
(J:86077)
• in 6 of 7 mice following treatment with cre-expressing adenovirus
(J:157319)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
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• developed in one mouse
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• fewer CASP3+ cells area found following UVB treatment when compared to wild-type mice
• the reduction in apoptotic cells is slightly greater in homozygotes than in heterozygotes
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• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• skin tumors develop between 500 and 600 days
• UVB exposure results in 2.4+/-0.6 tumors at day 100 compared to 6.5+/-1.4 in Trp53tm3Tyj Tg(KRT14-cre)8Brn heterozygotes and 0.6+/-0.2 in wild-type mice
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
|
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• fewer CASP3+ cells area found following UVB treatment when compared to wild-type mice
• the reduction in apoptotic cells is slightly greater in homozygotes than in heterozygotes
|
|
• skin tumors develop between 500 and 600 days
• UVB exposure results in 2.4+/-0.6 tumors at day 100 compared to 6.5+/-1.4 in Trp53tm3Tyj Tg(KRT14-cre)8Brn heterozygotes and 0.6+/-0.2 in wild-type mice
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
|
|
• fewer CASP3+ cells area found following UVB treatment when compared to wild-type mice
• the reduction in apoptotic cells is slightly greater in homozygotes than in heterozygotes
|
|
• skin tumors develop between 200 and 300 days
• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present at weaning
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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